中国临床药理学杂志Issue(9)：689-692,4.DOI:10.13699/j.cnki.1001-6821.2015.09.003
西格列汀联合预混胰岛素对2型糖尿病患者血糖波动的影响
Effects of sitagliptin combined with premixed insulin on blood glucose fluctuations in patients with type 2 diabetes
徐芬娟 1宣少平 1张青森 1钟春惠 1沈中秋 1沈飞霞2
作者信息
- 1. 桐乡市第一人民医院 内分泌科，浙江 嘉兴314500
- 2. 温州医科大学 附属第一医院 内分泌科，浙江 温州 325035
- 折叠
摘要
Abstract
Objective To investigate the effects of sitagliptin combined with premixed insulin on blood glucose fluctuations in patients with type 2 diabetes.Methods A total of 42 patients with type 2 diabetes from April 2012 to November 2013 were randomly divided into two groups, treated with insulin aspart 30 injections alone 2 to 3 times a day( control group, n=21 ) or combined with oral sitagliptin once a day ( treatment group, n=21).The glucose fluctuations by fingertip blood glucose and continuous glucose monitoring ( CGM) were assessed and the changes of glucose fluctuations in two groups before and after treatment were com-pared as well as the incidence of adverse reactions.Results Compared with before treatment, the data of blood glucose fluctuations index in two groups were significantly decreased after treatment.The fingertip blood glucose results showed that standard deviation of blood glucose( SDBG) , coefficient of varicotion( CV) and postprandial blood glucose index were lower in treatment group after treatment(P<0.05).The date from CGM showed SDBG [(1.77 ±0.53) vs ( 2.39 ±0.80 ) mmol · L-1 ], was significantly lower in treatment group than that in control group( P<0.05).MAGE and MODD in treatment group was decreased than control group [ MAGE ( 4.36 ±1.14 ) vs ( 5.82 ±2.44 ) mmol · L-1 and MODD ( 1.32 ±0.37 ) vs (1.71 ±0.65)mmol· L-1], but there was no statistical difference found(P >0.05).Hypoglycemia time ratio in treatment group was lower than that in control group [ ( 0.86 ±1.58 )% vs ( 2.95 ±2.39 )%, P <0.05 ].Conclusion Sitagliptin combined with premixed insulin is more safe and convenient for reducing blood glucose level and glucose fluctuations.关键词
西格列汀/预混胰岛素/2型糖尿病/血糖波动Key words
sitagliptin/premixed insulin/type 2 diabetes/glucose fluctuation分类
医药卫生引用本文复制引用
徐芬娟,宣少平,张青森,钟春惠,沈中秋,沈飞霞..西格列汀联合预混胰岛素对2型糖尿病患者血糖波动的影响[J].中国临床药理学杂志,2015,(9):689-692,4.
