中国临床药理学杂志Issue(10)：815-817,3.DOI:10.13699/j.cnki.1001-6821.2015.10.015
帕罗西汀和盐酸舍曲林治疗脑卒中后抑郁的临床疗效及安全性评价
Clinical efficacy and safety of paroxetine hydrochloride and sertraline hydrochloride in the treatment of post-stroke depression
李小明 1胡爱虹 1顾群2
作者信息
- 1. 湖州市第一人民医院药剂科，浙江湖州 313000
- 2. 湖州市第一人民医院临床药学室，浙江湖州 313000
- 折叠
摘要
Abstract
Objective To compare the clinical efficacy of paroxetine hydrochloride and sertraline hydrochloride in the treatment of post -stroke depression.Methods Sixty patients diagnosed with post -strke depression were recruited in this study and randomized divided into treat-ment group ( n=28 ) and control group ( n=32 ) .Patients in the treat-ment group were given paroxetine hydrochloride 20 mg・ d-1 orally and patients in the control group were given sertraline hydrochloride 50 mg・ d-1 orally.The treatment lasted for 12 weeks.The Hamilton rating scale for depression ( HAMD ) , National institute of health stroke scale ( NIHSS) and barthel index ( BI) were evaluated in every two weeks after the treatment.The score of HAMD, NIHSS, BI and adverse drug reac-tions were recorded and compared between the two groups .Results The clinical efficacy were 89.29% and 93.75% in the treatment group and control group respectively , without statistical difference ( P>0.05 ) .The score of HAMD , NIHSS and BI were significantly decreased after 12 weeks treatment in both groups ( P<0.05 ).But the scores at the end of the 12 weeks were not statistically different between the two groups ( P>0.05 ) . The incidence of adverse drug reactions were 21.43% and 18.75% in the treatment group and control group respectively with no statistical difference ( P>0.05 ) .Conclusion No statistical difference in clinical efficacy and safety were found between paroxetine hydrochloride and sertraline hydrochloride in the treatment of post-stroke depression , both with low incidence of adverse drug reactions .关键词
脑卒中后抑郁/盐酸帕罗西汀/盐酸舍曲林/临床疗效/安全性Key words
post-stroke depression/paroxetine hydrochloride/sertraline hydrochloride/clinical efficacy/safety分类
医药卫生引用本文复制引用
李小明,胡爱虹,顾群..帕罗西汀和盐酸舍曲林治疗脑卒中后抑郁的临床疗效及安全性评价[J].中国临床药理学杂志,2015,(10):815-817,3.
