中国临床药理学杂志Issue(10)：830-832,3.DOI:10.13699/j.cnki.1001-6821.2015.10.020
热休克蛋白70在脊髓损伤患者血清中的表达及临床意义
Temporal expression profile of HSP70 in serum of patients with spinal cord injury and its clinical significance
摘要
Abstract
Objective To investigate the expression of serum heat shock protein 70 ( HSP70 ) in patients with spinal cord injury and its correlation with the extent of injury severity .Methods There were 76 patients with spinal cord injury in experiment group , and 30 healthy volunteers enrolled in control group.Blood samples were obtained at 6, 12, 24, 72 , 120 h after spinal cord injury in 76 patients.Western blot analysis was used to determine the expression of HSP 70 and the correlation between HSP70 level and the extent of injury severity was also evaluated . Results The patients with spinal cord injury showed a higher expression of HSP70 than control group at 6 h, and peaked at 12 h.But the expression decreased 72 , 120 h post spinal cord injury ( P<0.05 ) . Furthermore , the level of HSP70 was positively correlated with the extent of injury severity in spinal cord injury patients ( P <0.05 ) . Conclusion Increased serum HSP70 level may constitute an early predictor of unfavorable outcome in spinal cord injury patients .关键词
脊髓损伤/热休克蛋白70Key words
spinal cord injury/heat shock protein 70 ( HSP70 )分类
医药卫生引用本文复制引用
管四炎,胡涌亮,余斌,王国庆,汪晓凡,陈森..热休克蛋白70在脊髓损伤患者血清中的表达及临床意义[J].中国临床药理学杂志,2015,(10):830-832,3.基金项目
湖北省教育厅课题基金资助项目 （）
