中国临床药理学杂志Issue(10)：836-839,4.DOI:10.13699/j.cnki.1001-6821.2015.10.022
水黄皮胶囊剂的抗炎作用及其机制研究
Study on the anti -inflammatory effects and its mechanism of Pongamia pinnata capsules
摘要
Abstract
Objective To compare the anti -inflammatory effects of Pongamia pinnata capsules and the ethanolic extract of Pongamia pinnata roots ( PRE ) , and to explore its anti -inflammatory mechanism . Methods The acute and chronic inflammation models were estab-lished.The mice were randomly divided into 8 groups ( 8 mice per group),model group(0.5%CMC-Na),positive control group ( aspirin, 0.5 g・ kg -1 ) , PRE and Pongamia pinnata capsules of the high dose group, middle dose group and low dose group (in accordance with 20.0, 8.0 ,3.2 g・ kg -1 raw herbs ) .The SD rats were randomly divided into 6 groups ( 8 mice per group ) , blank group ( 0.9%NaCl ) , model group (0.5% CMC -Na), positive control group ( aspirin,0.3 g・ kg -1 ), Pongamia pinnata capsules of the high dose group , middle dose group and low dose group ( in accordance with 13.3 , 5.3 , 2.1 g・ kg -1 raw herbs),gavage once daily for 7 d.The duratoin was 7 days.The patho-logical changes of paw inflammatory tissue were observed and the contents of interleukin -1β( IL -1β) , tumour necrosis factor -alpha ( TNF-α) and prostaglandin E 2 ( PGE2 ) in toe tissue were measured . Results The same dose of Pongamia pinnata capsules and PRE group all showed anti -inflammatory effects.In addition,the release of IL -1β, TNF -αand PGE2 could be inhibited. Conclusion There is a significant anti-inflammatory effects about Pongamia pinnata capsules and its mechanism may be related to reducing IL-1β, TNF-αand PGE2 levels.关键词
水黄皮/水黄皮胶囊/抗炎作用/机制Key words
Pongamia pinnata/Pongamia pinnata capsules/anti-inflammation/mechanism分类
医药卫生引用本文复制引用
肖成燕,朱毅,董志,封莎,向丽..水黄皮胶囊剂的抗炎作用及其机制研究[J].中国临床药理学杂志,2015,(10):836-839,4.基金项目
海南省中药现代化专项基金资助项目 （）
