中国临床药理学杂志Issue(10)：874-877,4.DOI:10.13699/j.cnki.1001-6821.2015.10.032
通心络胶囊改善小鼠糖尿病周围神经病变的保护作用
Protective effect of Tongxinluo capsule on diabetic peripheral neuropathy in mice
摘要
Abstract
Objective To investigate the effect of Tongxinluo capsule on diabetic peripheral neuropathy in mice .Methods KK/Upj -Ay mice were randomly divided into 4 groups,model, Tongxinluo low, middle, high doses groups (0.8, 0.4, 0.2 g・ kg -1 ).C57BL/6 mice were se-lected as control group.Mice were given intragastrically for 12 weeks. Motor nerve conduction velocity ( MNCV ) and sensory nerve conduction velocity ( SNCV) were detected.The expression of tumor necrosis factor alpha ( TNF -α) , interleukin 6 ( IL -6 ) and interleukin 1 beta (IL-1β) and nuclear factor kappa B (NF-κB) in sciatic nerve were examined by real time PCR and Western blot .Results Compared with model group , MNCV and SNCV were faster ( P<0.05 , P<0.01 ) .The TNF-α, IL-6 , IL-1βand NF-κB expression significantly were de-creased in Tongxinluo group ( P < 0.05 , P < 0.01 ) . Conclusion Tongxinluo capsule inhibits inflammatory cytokines expres-sion in diabetic peripheral neuropathy mice by inhibiting NF -κB pathway , to ameliorates diabetic peripheral neuropathy .关键词
通心络胶囊/糖尿病周围神经病变/炎症因子/NF-κB通路Key words
Tongxinluo capsule/diabetic peripheral neuropathy/inflammatory cytokines/nuclear factor kappa B pathway分类
医药卫生引用本文复制引用
王超,张会欣,邢邯英,王杏,刘敏..通心络胶囊改善小鼠糖尿病周围神经病变的保护作用[J].中国临床药理学杂志,2015,(10):874-877,4.基金项目
“十二五”重大新药创制科技重大专项基金资助项目（2011ZX09101-004-02）；河北省中医药管理局科研计划基金资助项目 （）
