中国临床药理学杂志Issue(11)：924-927,4.DOI:10.13699/j.cnki.1001-6821.2015.11.008
细胞色素P4502C8和细胞色素P4502J2基因多态性与中国汉族散发性阿尔茨海默病的相关性研究
Relationship between genetic polymorphisms of cytochrome P4502C8 and cytochrome P4502J2 with the risk of Alzheimer′s disease in Chinese Han population
摘要
Abstract
Objective To detect the association between cytochrome P450 2C8 ( CYP2C8 ) and CYP2C9 polymorphisms and the risk of Alzheimer′s disease ( AD ) in Chinese Han population.Methods A case-control study was carried out to compare the distribution of geno-types and genetic frequencies of CYP2C8 and CYP2C9 polymorphisms between Alzheimer′s disease ( n =206 ) and healthy volunteers ( n=256 ) .Genomic DNA was extracted from whole blood using DNA blood Kit.Matrix-assisted laser desorption ionization time-of -flight mass spectrometry ( MALDI-TOF-MS) .Matrix-assisted laser desorp-tion ionization time-of-flight mass spectrometry ( MALDI-TOF-MS) was used to identify the polymorphisms of CYP2C8 and CYP2J2. Results There were no significant differences of CYP2C8 and CYP2C9 genotypes between the cases and control groups.The haplotype C-T of CYP2C8 associated with the AD group( P<0.001,OR=2.57,95%CI:1.97 -3.35 ) .Conclusion The haplotype C -T of CYP2C8 ( rs1058932, rs2275622 ) increased the risk of Alzheimer′s disease in Chinese Han population.关键词
阿尔茨海默病/细胞色素P4502C8/细胞色素P4502J2/基因多态性Key words
Alzheimer′s disease/cytochrome P4502 C8/cytochrome P4502 J2/genetic polymorphism分类
医药卫生引用本文复制引用
贺宝霞,严华成,黄牧坤,张文周,赵秀莉..细胞色素P4502C8和细胞色素P4502J2基因多态性与中国汉族散发性阿尔茨海默病的相关性研究[J].中国临床药理学杂志,2015,(11):924-927,4.基金项目
国家自然科学基金资助项目（81100945）；广州市珠江科技新星专项基金资助项目 （）
