中国临床药理学杂志Issue(12)：1079-1081,3.DOI:10.13699/j.cnki.1001-6821.2015.12.001
依达拉奉联合神经节苷脂治疗老年急性脑梗死的临床疗效及安全性评价
Effect and safety of edaravone combined with ganglioside in treatment of acute cerebral infarction of elderly patients
摘要
Abstract
Objective To evaluate the clinical effect of edaravone com-bined with ganglioside in treatment of acute cerebral infarction of elderly patients and its effect on inflammation factors.Methods A total of 74 cases of acute cerebral infarction were included in this study from Sep-tember 2012 to November 2014 and randomized divided into treatment group(n=36)and control group(n=38).All the included patients were given basic treatment such as anticoagulation and depressurization regi-men.Patients in the treatment group were administered with edaravone 30 mg+0.9% sodium chloride 250 mL through intravenous transfusion plus ganglioside 60 mg+0.9 sodium chloride 250 mL intravenous trans-fusion.Patients in the control group were administered Xue Shuan Tong 200 mg+0.9%sodium chloride 250 mL through intravenous transfusion. The treatment lasted for 4 weeks in two groups.One week after treatment, the data of clinical efficacy, tumor necrosis factor α( TNF -α) , C-reactive protein and interleukin-6 were compared between the two groups.Results The total efficacy were 91.67% and 71.05% in the treatment and control group ( P <0.05 ) . The inflammation factors ( TNF-α, C-reactive protein and interleukin -6 ) were significantly decreased after treatment(P<0.05).And the adverse event incidence rate was not statistically different between the two groups(P>0.05).Conclusion Significant clinical efficacy is found in the regimen of edaravone combined with ganglioside for treatment of acute cerebral infarction in elderly patients and the inflammation factors can be significantly decreased.关键词
急性脑梗死/依达拉奉/神经节苷脂/临床疗效/炎症因子Key words
acute cerebral infarction/edaravone/ganglioside/clinical effect/inflammation factor分类
医药卫生引用本文复制引用
顾群..依达拉奉联合神经节苷脂治疗老年急性脑梗死的临床疗效及安全性评价[J].中国临床药理学杂志,2015,(12):1079-1081,3.基金项目
浙江省湖州市科技局基金资助项目 （）
