中国临床药理学杂志Issue(12)：1099-1102,4.DOI:10.13699/j.cnki.1001-6821.2015.12.007
糖脉康颗粒对2型糖尿病患者胰岛素敏感性的临床疗效观察
Clinical efficacy of Tangmaikang particles on insulin sensitivity in treatment of type 2 diabetes
袁群 1俞璐 1邵致格 1丁康钰 1盛丽 1韦亚萍 1李珂1
作者信息
- 1. 常州市中医医院 内分泌科，江苏 常州213000
- 折叠
摘要
Abstract
Objective To observe the effect of Tangmaikang particles on insulin sensitivity in the treatment of type 2 diabetes.Methods A total of 120 patients with type 2 diabetes were selected, randomly divided into control group ( n=60) and treatment group ( n=60).Patients in control group received routine hypoglycemic, hypotensive and lipid adjusting treatment, while patients in treatment group were given Tangmaikang par-ticles 15 g・ d-1 on the basis of conventional treatment.The treatment lasted for 3 months.The data of postprandial plasma sugar ( PPG) , gly-cosylated hemoglobin ( HbA1 c ) , fasting insulin ( FINS ) , insulin sensi-tivity ( HOMA-IS ) , low density lipoprotein ( LDL -C ) , triglyceride (TG), endothelin -1( ET-1) and the change of clinical symptoms in two groups before and after treatment were observed as well as the inci-dence of adverse reactions in 2 groups.Results The total effective rate was 88.33% in treatment group, better than control group (75.00%) .After treatment, the data of FINS, HOMA -IS, PPG, HbA1c were all significantly improved in two groups( P<0.05 ) , and treatment group improved more obviously than control group ( P<0.05 ) .Symptoms in two groups were both improved compared with before treatment( P<0.05) , and the treatment group was better than control group( P<0.05).But the TG level wasn′t significantly decreased in two groups( P>0.05).After treatment, LDL-C and ET-1 level in treatment group were significantly decreased ( P<0.05 ) , and the control group was not obvious (P>0.05).After the treatment for early diabetic nephropathy, ET -1 in treatment group was significantly lower (P<0.05), and the control group was not obvious (P>0.05).There was no adverse reactions found during treat-ment.Conclusion Tangmaikang particles are safe and effective for type 2 diabetes, which also can improve insulin sensibility, reduce insulin resistance and ET-1 level, especially can reduce the ET-1 level of patients with diabetic nephropathy.关键词
糖尿病/糖脉康/胰岛素/内皮素-1Key words
diabetes/Tangmaikang/insulin/endothelin-1分类
医药卫生引用本文复制引用
袁群,俞璐,邵致格,丁康钰,盛丽,韦亚萍,李珂..糖脉康颗粒对2型糖尿病患者胰岛素敏感性的临床疗效观察[J].中国临床药理学杂志,2015,(12):1099-1102,4.
