中国临床药理学杂志Issue(12)：1112-1115,4.DOI:10.13699/j.cnki.1001-6821.2015.12.011
不同剂量舒芬太尼联合异丙酚用于无抽搐电休克的临床疗效和安全性评价
Safety and efficacy of the different doses of sufentanil combined with propofol target controlled infusion for modified electronic convulsive therapy
摘要
Abstract
Objective To compare the safety and efficacy of the different doses of sufentanil combined with propofol target controlled infusion for modified electronic convulsive therapy ( MECT ) .Methods A total of 100 patients with mental disorders were randomly divided into four groups:control group (group C), sufentanil 1 group (S1), sufentanil 2 group ( S2 ) and sufentanil 3 group ( S3 ) , 25 cases in each group.In sufentanil groups, patients were respectively intravenously injected with 0.1, 0.2 and 0.3 μg・ kg -1 sufentanil 10 mL, and those in control group were given 0.9%NaCl solution.Propofol was given through target controlled infusion, and the initial target density of 3.0 μg・ mL-1 was set, and increased by 0.5μg・ mL-1.When eyelash reflex disappeared, succinylcholine 1.0 mg・ kg -1 was injected by intravenous injection.The vital signs of patients before anesthesia ( T1 ) , target control infusion stop immediately ( T2 ) , immediately after MECT finished ( T3 ) and consciousness recovery ( T4 ) , clinical effects,the seizure energy index, the seizure duration, awakening time, assisted ventilation time and adverse reactions were recorded.Results The difference had no statistical significance in vital signs, the seizure energy index, the seizure duration of all patients ( P >0.05 ) .Compared with group C, assisted ventilation in group S2 and S3 was prolonged, and the waking time was extended in group S3, total effective rate was increased in group S1 to S3 ( P<0.05 ) .Compared with group S1 , assisted ventilation time and waking time were extended, myalgia was decreased, and the total effective rate was increased in group S3(P<0.05).Compared with group S2 , the assisted ventilation was prolonged in group S3 ( P<0.05 ) .The incidences of nausea and vomiting and sleepiness were increased, while muscle pain and headache incidence were decreased as sufentanil dose increased. Conclusion Sufentanil combined with anesthesia of propofol target controlled infusion can be safe and effective for MECT, and 0.2 μg・ kg-1 sufentanil is preferred.关键词
舒芬太尼/异丙酚/无抽搐电休克Key words
sufentanil/propofol/modified electronic convulsive therapy分类
医药卫生引用本文复制引用
田长征,郭琼梅,郝雪莲,周长浩..不同剂量舒芬太尼联合异丙酚用于无抽搐电休克的临床疗效和安全性评价[J].中国临床药理学杂志,2015,(12):1112-1115,4.基金项目
河北省科技局卫生厅基金资助项目 （）
