中国临床药理学杂志Issue(12)：1154-1156,3.DOI:10.13699/j.cnki.1001-6821.2015.12.023
黄芩对阿尔茨海默病模型小鼠海马及大脑皮质胆碱相关酶的影响
Effects of Scutellaria baicalensis Georgi on choline enzyme in hippocampus and cerebral cortex of the Alzheimer′s disease model mice
崔晓燕 1张敏 1刘晓明1
作者信息
- 1. 河北省药品检验研究院 药理毒理室，石家庄050011
- 折叠
摘要
Abstract
Objective To investigate the effects of Scutellaria baicalen-sis Georgi ( SBE ) on the activity of acetyl cholinesterase ( AChE ) and choline acetyltransferase ( ChAT) in hippocampus and cerebral cortex of the Alzheimer′s disease ( AD) model mice which induced by D-gal and NaNO2.Method AD model mice caused by D-gal (150 mg・ kg -1 ) and NaNO2 (100 mg・ kg-1 ) were intragastric administrad with 125, 250 and 500 mg・ kg-1・ d -1 SBE for 60 d.In 60 d after administration, mice were beheaded put to death,the protein content in cortex and hippo-campus were determinate, and the effect of SBE on the activity of AChE and ChAT in hippocampus and cerebral cortex were examined by Kits. Result The activity of AChE was higher and ChAT was lower in hippo-campus and cerebral cortex of the AD model mice than in the normal group.While in the AD model mice treated with SBE 500 mg・ kg-1・ d-1 , the activity of AChE in the hippocampus was significantly decreased, on the other hand, the activity of ChAT in the hippocampus was significantly increased.Treated with SBE 250,500 mg・ kg-1・ d-1 , the activity of ChAT in the cerebral cortex was significantly enhanced. Conclusion These results indicated that SBE encourages the synthesis and inhibits the decomposition of choline enzyme in hippocampus and cerebral cortex of the AD model mice.关键词
黄芩提取物/乙酰胆碱酯酶/胆碱乙酰转移酶/蛋白含量Key words
Scutellaria baicalensis Georgi/acetyl cholinesterase/choline acetyltransferase/protein level分类
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崔晓燕,张敏,刘晓明..黄芩对阿尔茨海默病模型小鼠海马及大脑皮质胆碱相关酶的影响[J].中国临床药理学杂志,2015,(12):1154-1156,3.
