中国临床药理学杂志Issue(13)：1246-1248,3.DOI:10.13699/j.cnki.1001-6821.2015.13.008
氨甲环酸对膝关节置换术后血红蛋白降低的临床研究
Clinical effects of knee replacement postoperative reducing hemoglobin of tranexamic acid application
摘要
Abstract
Objective To investigate the effects of knee replacement postoperative on reducing hemoglobin by the different doses of tranexamic acid application.Methods A total of 116 knee replacement patients were enrolled and divided into the treatment group and the control group , 58 cases in each group .The surgical procedures and methods of the two groups were same , as patients in the control group were given intrave-nously before incision tranexamic acid 50 mg・ kg -1 , and those in the treatment group received tranexamic acid 100 mg・ kg -1 . During the peri-operative phase , the index of operation time , incision size , blood loss during operation , post -surgery drainage and the total number of blood transfusion , as well as hemoglobin were observed . Results Patients in two groups were all discharged after successful com-pletion surgery .The blood loss , postoperative drainage , the total amount of blood transfusion of the treatment group were significantly less than those of control group ( P<0.05 ) .The postoperative values in the two groups were showed significantly decreased ( P<0.05 ) , but preoperative hemoglobin values of the treatment group were significantly higher (P<0.05).The data of preoperative and postoperative coagulation indicators compared between two groups showed no significant difference .Patients were followed up for 3 months.The incidence of complications of deep vein thrombosis (1 case), acute myocardial infarction ( 0 case), transient neuro-logical symptom (1 case) in the treatment group were significantly lower than that in control group (5, 3, 4 cases) (P<0.05).Conclusion High dose of tranexamic acid applications can reduce blood loss and transfusion knee re -placement volume , and relieve the postoperative decrease of hemoglobin , meanwhile , it has no obvious effect on coagu-lation function with defined security .关键词
氨甲环酸/剂量/膝关节置换术/血红蛋白Key words
tranexamic acid/dose/knee arthroplasty/hemoglobin分类
医药卫生引用本文复制引用
徐飞,董晓强,何文静,张艳波,吕永明,宋莺春,李霞,邢恩鸿,杨阳,杜元良,张立超,戴海峰..氨甲环酸对膝关节置换术后血红蛋白降低的临床研究[J].中国临床药理学杂志,2015,(13):1246-1248,3.基金项目
承德市科学技术研究与发展计划基金资助项目 （）
