中国临床药理学杂志Issue(13)：1262-1264,3.DOI:10.13699/j.cnki.1001-6821.2015.13.013
注射用甲磺酸桂哌齐特对局灶性缺血脑梗死大鼠的神经改善作用
Improving effects of mesylate cinepazide on neurological function of focal cerebral ischemia in rats
王建波 1潘玉兴 1程振田1
作者信息
- 1. 潍坊市益都中心医院 药学部，山东 青州262500
- 折叠
摘要
Abstract
Objective To investigate the effect of mesylate cinepazideon on focal cerebral ischemia infarction in rats .Methods Sprague -Daw-ley(SD) rats were randomly divided into six groups:sham group, model group, control group ( cinepazide maleate 29 mg・ kg-1 ) , three doses test groups (mesylate cinepazideon,45,22.5,11.25 mg・ kg -1).Twenty-four hours after administration , Zea -Longa method was used to assessment the neurological disfunction scores .Triphenyltetrazolium chlo-ride ( TTC) staining was used to measure cerebral infarction size .Histo-pathology were determined with hematoxylin - eosin staining. Results Compared with model group , the infarction area were signifi-cantly reduced in high , middle test groups ( 45 , 22.5 mg・ kg -1 ) and control group.And neurologic function were improved in high , middle doses test groups.Conclusion Infarction area was reduced and neuro-logical function was improved on nerve cells after administration .关键词
甲磺酸桂哌齐特/局灶性脑缺血/梗死面积/梗死率Key words
mesylate cinepazideon/focal cerebral ischemia infarction/infarct size/infarction rate分类
医药卫生引用本文复制引用
王建波,潘玉兴,程振田..注射用甲磺酸桂哌齐特对局灶性缺血脑梗死大鼠的神经改善作用[J].中国临床药理学杂志,2015,(13):1262-1264,3.
