中国临床药理学杂志Issue(13)：1328-1330,3.DOI:10.13699/j.cnki.1001-6821.2015.13.034
甾体激素类药物与细胞色素 P450代谢酶系相互作用的研究进展
Progress in research of the interaction between the steroid hormone drugs and cytochrome P450 metabolic enzymes
摘要
Abstract
Steroid hormones are mainly consisted of glucocorticoid , estro-gen, progesterone, androgen and vitamin D.The common clinical used steroid hormone drugs are mainly the derivatives or synthetic compounds of the steroid hormones.Cytochrome P450 (CYP450), a super family of the heme-thiolate proteins, plays a vital role in both the synthetic and metabolic process of the steroid hormones .However , the steroids could also influence the mRNA expression and metabolic activity of the CYP450.Consequently ,the interaction between the steroids and CYP 450 may determine the human ’ s susceptibility to many diseases such as tumour , inflammation or autoimmune diseases and can also influence the drug’s therapic effect.In this review, we introduce the recent progress in the interaction between the steroid hormones and CYP 450.关键词
甾体激素/细胞色素P450/代谢/诱导Key words
steroid hormones/cytochrome P450/metabolism , induction分类
医药卫生引用本文复制引用
程海旭,章国良..甾体激素类药物与细胞色素 P450代谢酶系相互作用的研究进展[J].中国临床药理学杂志,2015,(13):1328-1330,3.基金项目
国家自然科学基金资助项目 （）
