摘要
Abstract
Objective To systematic evaluate whether combining drugs influence renal function could increases the risk of nephrotoxicity caused by vancomycin. Methods Electronic databases such as PubMed , EMBase, the Cochrane library and Chinese database (CNKI, WanFang, CBM) were searched from establishment dates of databases to January 2014.The clinical observational studies which include vancomycin com-bines other drugs which could influence renal function was identified . The studies were screened according to the inclusion and exclusion crite-ria, the data were extracted, the quality of the included studies was as-sessed , and Meta-analysis was performed using RevMan 5.3 software. Results A total of six cohort studies were included , containing 1312 pa-tients, 791 patients of them using vancomycin alone , the other 521 patients combining other renal influence drugs .Compare with singly using vancomy-cin, combining renal influence drugs could increase nephrotoxicity signifi-cantly(P<0.01), but the heterogeneity is huge(P<0.05).After the sensi-tivity analysis , nephrotoxicity increasing still significantly ( P <0.01 ) . Conclusion Combining drugs which influence renal function could increase nephrotoxicity caused by vancomycin , so we should avoid combining drugs in clinical practice , or focus on monitoring when combining .关键词
万古霉素/肾毒性/影响肾功能药物/系统评价/Meta分析Key words
vancomycin/nephrotoxicity/drugs influence renal function/systematic review/Meta-analysis分类
医药卫生
