中国临床药理学杂志Issue(13)：1344-1347,4.DOI:10.13699/j.cnki.1001-6821.2015.13.039
肿瘤患者万古霉素治疗药物监测的系统评价和 Meta分析
Systemic review and Meta -analysis of therapeutic drug monitoring in cancer patients
董芊汝 1赵夕岚 2翟所迪1
作者信息
- 1. 北京大学第三医院药剂科，北京 100191
- 2. 北京大学 药学院 药事管理与临床药学系，北京 100191
- 折叠
摘要
Abstract
Objective To systematic evaluate the necessity of vancomy-cin therapeutic drug monitoring in cancer patients .Methods Electronic databases such as PubMed , EMBase, Cochrane library and Chinese data-base (CNKI, WanFang, CBM) were searched from establishment dates of databases to January 2014.The clinical observational studies which in-clude cancer patients using vancomycin intravenously was identified .The studies were screened according to the inclusion and exclusion criteria , the data were extracted , the quality of the included studies was assessed , and Meta -analysis was performed using Rev Man 5.3 software. Results Six cohort studies were identified .Compared with no -cancer patients, infectious treatment failure increases significantly (P<0.05), the target concentration rate of vancomycin decrease significantly (P<0.05).Conclusion As the decrease of target concentration rate and increase of treatment failure , cancer patients need therapeutic drug monitoring ( TDM) to adjust the dose of vancomycin .关键词
万古霉素/治疗药物监测/肿瘤/系统评价Key words
vancomycin/therapeutic drug monitoring/cancer/system-atic review分类
医药卫生引用本文复制引用
董芊汝,赵夕岚,翟所迪..肿瘤患者万古霉素治疗药物监测的系统评价和 Meta分析[J].中国临床药理学杂志,2015,(13):1344-1347,4.
