中国临床药理学杂志Issue(14)：1373-1375,3.DOI:10.13699/j.cnki.1001-6821.2015.14.004
阿法骨化醇软胶囊对慢性阻塞性肺疾病患者免疫功能的临床研究
Effect of alfacalcidol soft capsules on immune function in patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the effect of alfacalcidol soft capsules on immune function in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 172 COPD patients were random-ly divided into the trial group ( n=86 ) and the control group ( n=86 ) . They all accepted the conventional treatment, but the patients in the trial group were given the treatment of alfacalcidol soft capsules 0.25μg・ d -1 for 6 months.The difference of immune function ( CD3 +, CD4 +, CD8 +and CD4 +/CD8 +), pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, diffusion capacity for carbon monoxide of lung/alveolar volume ( DLCO/VA ) ] and acute exacerbations of COPD during 6 months follow -up were compared between the two groups.Results The contrations of CD3 +, CD4 +, CD8 +and CD4 +/CD8 +after treatment in the trial group were significantly higher than that before treatment and control group (P<0.05).The FEV1,FEV1/FVC,DLCO/VA after treatment in the trial group were significantly higher than that before treatment and control group(P<0.05).There were no significant difference of CD3 +,CD4 +, CD8 +, CD4 +/CD8 +, FEV1, FEV1/FVC, DLCO/VA before and after treatment in the control goup(P>0.05).The rate of acute exacerbations of COPD in the trial group (9.30%)was sig-nificantly lower than that in the control group ( 25.58%) during 6 months follow-up.Conclusion Alfacalcidol soft capsules could improve the pulmonary function and reduce acute exacerbations by improving immune function of patients with COPD.关键词
阿法骨化醇软胶囊/免疫功能/慢性阻塞性肺疾病/肺功能Key words
alfacalcidol soft capsule/immune function/chronic obstructive pulmonary disease/pulmonary function分类
医药卫生引用本文复制引用
顾海艇,邵海燕,金晓红,毛文炜..阿法骨化醇软胶囊对慢性阻塞性肺疾病患者免疫功能的临床研究[J].中国临床药理学杂志,2015,(14):1373-1375,3.基金项目
浙江省科技计划基金资助项目 （）
