中国临床药理学杂志Issue(14)：1422-1425,4.DOI:10.13699/j.cnki.1001-6821.2015.14.020
6－苄胺基嘌呤对 D－半乳糖致小鼠脑组织氧化损伤的保护作用
Protective effects of 6-benzylaminopurine against oxidative damage in brain tissue of mice induced by D-galactose
摘要
Abstract
Objective To study the protective effects of 6 -benzylami-nopurine (6-BA) on oxidative injury in mice brain induced by D-ga-lactose ( D-gal).Methods The mice were randomly divided into four groups, and named control group, model group, low dose experimental group, and high dose experimental group.Brain injury model was in-duced by D-gal.Mice in experimental group were administrated by 6-BA (20, 40 mg・ kg -1 ) by gavage once daily for 6 weeks.The activities of total -superoxide dismutase ( T -SOD ) , glutathione peroxidase ( GSH-Px) , and the content of malondialdehyde ( MDA) were detected by spectrophotometer.Histological features of mice brain were observed by HE staining and DNA oxidative damage was measured by single cell gel electrophoresis.Results Compared with model group, treatment of 6-BA inhibited significantly MDA generation and increased the activities of T -SOD and GSH -Px, and improve significantly morphology and DNAdamageinducedbyD-gal.Conclusion 6-BAhasprotective effects against oxidative damage in brain tissue of mice induced by D-gal.关键词
6-苄氨基嘌呤/脑组织/海马/氧化损伤Key words
6-benzylaminopurine/brain tissue/hippocampus/oxida-tive damage分类
医药卫生引用本文复制引用
张自强,刘玉梅,位兰,朱雪敏,黄婷婷,张春燕..6－苄胺基嘌呤对 D－半乳糖致小鼠脑组织氧化损伤的保护作用[J].中国临床药理学杂志,2015,(14):1422-1425,4.基金项目
国家自然科学基金资助项目 （）
