中国临床药理学杂志Issue(14)：1426-1428,3.DOI:10.13699/j.cnki.1001-6821.2015.14.021
蜗牛多肽对大鼠皮肤烫伤创面的愈合及碱性成纤维生长因子 mRNA表达的影响
Effect of snail polypeptide on skin healing and expression of basic fibroblast growth factor mRNA in rats with scalded wound
摘要
Abstract
Objective To investigate effect of snail polypeptide on skin healing and expression of basic fibroblast growth factor ( bFGF) mRNA in rats with scalded wound.Methods The deepⅡscald model was estab-lished in 60 rats by using 90 ℃ hot water.And the rats were randomly divided into model group and the test group.Rat burn sites in test group were smeared with SP solution(10 mg・ mL-1 ).Skin healing rate,skin healing time and the scab off time were observed in each group of rats. The mRNA expression of skin tissue bFGF was detected by RT-PCR. Results Healing rate of test group at different times after treatment were significantly higher than the model group, with statistically significant difference ( P <0.05 or P <0.01 ) .Compared with the model group, burn the skin healing time scab off times are significantly shorter in test group, the difference was statistically significant ( P <0.05 ) .Mean-while, SP increased the expression of bFGF mRNA at different times. Conclusion SP can promote wound healing in rat skin burns, and its mechanism may be related to regulating bFGF mRNA expression.关键词
蜗牛多肽/烫伤/愈合/碱性成纤维生长因子Key words
snail polypeptide/scalded wound/skin healing/basic fibroblast growth factor分类
医药卫生引用本文复制引用
曹鹏涛,李世朋,张露露,张培哲,袁晓晗,安君岭,席守民..蜗牛多肽对大鼠皮肤烫伤创面的愈合及碱性成纤维生长因子 mRNA表达的影响[J].中国临床药理学杂志,2015,(14):1426-1428,3.基金项目
国家级大学生创新创业训练计划基金资助项目（201210464021）；河南科技大学大学生研究训练计划基金资助项目 （）
