中国临床药理学杂志Issue(14)：1429-1431,3.DOI:10.13699/j.cnki.1001-6821.2015.14.022
窄谱中波紫外线联合他克莫司对白癜风模型表皮中黑色素表达的影响
Influence of combination of narrow band ultraviolet B and tacrolimus ointment on skin melanin expression in models with vitiligo
摘要
Abstract
Objective To investigate the changes in the number of skin melanin after combined treatment of narrow band ultraviolet B ( NB-UVB) and tacrolimus ointment in animal models with vitiligo. Methods Animal models with vitiligo were built first.And then all the animal models were randomly divided into six groups of eight according to the principle of weight balance:normal group,model group,control group ( where vaseline was used in the shed white spot areas in the back of animal model, these two methods were implemented 2 times per day ), medication alone group(0.03%tacrolimus ointment skin smear,these two methods were implemented 2 times per day), light alone group(white spot area use NB-UVB irradiation, these two methods were irradiation once every other day ) , combination group ( topical tacrolimus combination NB-UVB irradiation,frequency,method and time same to medication a-lone group and light alone group).The differences of the number of mela-nin in the skin tissue before and after medication were checked and com-pared and irradiation by histopathology.Results The effect of the com-bined group on skin melanin express was significantly different compared with model group ( P<0.01 ) .Conclusion Combination of NB -UVB and tacrolimus ointment has a significant effect on vitiligo treatment.关键词
白癜风/他克莫司软膏/窄谱中波紫外线/黑色素Key words
vitiligo/tacrolimus ointment/narrow band ultraviolet B/melanin分类
医药卫生引用本文复制引用
焦亚宁,姜敏,李军晖,刘晓帅,鈡振东,夏莉,梁莉,汪京峡..窄谱中波紫外线联合他克莫司对白癜风模型表皮中黑色素表达的影响[J].中国临床药理学杂志,2015,(14):1429-1431,3.基金项目
宁夏自然科学基金资助项目 （）
