中国临床药理学杂志Issue(14)：1462-1465,4.DOI:10.13699/j.cnki.1001-6821.2015.14.032
谷氨酸在晕动病发病机制中的作用及相关药物研究
Influence of glutamate on the pathogenesis of motion sickness and relative drugs research
摘要
Abstract
Glutamate is not only the major excitatory neurotransmitter in the central nervous system of human and mammalian animals but also participates the synaptic transmission of peripheral sensory system.How-ever, overstimulation of glutamate receptors by excessive glutamate leads to glutamate excitotoxicity.This review discusses the neurotransmission of glutamate in the vestibular end organs and the excitotoxicity by glutamate on them in motion sickness as well as the antimotion sickness drugs asso-ciated with glutamate neurotransmission.关键词
谷氨酸/晕动病/兴奋性神经毒性/离子通道拮抗剂/谷氨酸受体拮抗剂Key words
glutamate/motion sickness/excitatory neurotoxicity/ion channel antagonist/glutamate receptor antagonist分类
医药卫生引用本文复制引用
吕达娜,林淑瑜,黄阳,杨昌云..谷氨酸在晕动病发病机制中的作用及相关药物研究[J].中国临床药理学杂志,2015,(14):1462-1465,4.基金项目
南京军区医药卫生科研基金资助项目 （）
