中国临床医学Issue(6)：677-679,3.
2型糖尿病患者的血脂指标与糖尿病肾病的相关性研究
Research on Correlation between Serum Lipid Levels and Diabetic Nephropathy in Patients with Type 2 Diabe-tes Mellitus
施亚男 1施羽 1李晓峰 1卫东琴 1樊春笋 1张亚玮1
作者信息
- 1. 江苏省启东市人民医院内分泌科，病因室，江苏启东 226200
- 折叠
摘要
Abstract
Objective:To analyze the correlation between serum lipid levels and diabetic nephropathy in patients with type 2 di-abetic mellitus.Methods:A total of 240 patients with type 2 diabetic mellitus from Jun 2011 to Jul 2013 were enrolled.There were 100 patients with diabetic nephropathy and 140 patients without any complication.Gender,age,duration of diabetes, baseline fasting glucose,glycosylated hemoglobin and serum lipid were compared between the two groups.The odds ratio(OR) and 95% confidence interval(CI)of correlation between these factors and diabetic nephropathy were calculated and analyzed with Logistic regression model.Results:The differences of age,duration of diabetes,systolic pressure between the two groups were statistically significant(P <0.01).Adjusted Logistic regression model showed that age> 70(OR= 2.92,95% CI:1.31-6.51),duration of diabetes>10 years(OR=3.33,95%CI:1.79-6.16),diastolic pressure>90 mmHg(OR=2.23,95%CI:1.06-4.69),and low density lipoprotein>3.64 mmol/L(OR=2.85,95%CI:1.16-7.03)were independent risk factors for type 2 Dia-betic Mellitus complicated by diabetic nephropathy(P <0.01 and 0.05).Conclusions:Low density lipoprotein has the potential to be a predictive,prophylactic and therapeutic target for diabetic nephropathy.关键词
血脂异常/2 型糖尿病/糖尿病肾病/病例对照研究Key words
Dyslipidemia/Type 2 diabetic mellitus/Diabetic nephropathy/Case-control study分类
医药卫生引用本文复制引用
施亚男,施羽,李晓峰,卫东琴,樊春笋,张亚玮..2型糖尿病患者的血脂指标与糖尿病肾病的相关性研究[J].中国临床医学,2014,(6):677-679,3.
