中国临床医学Issue(1)：73-75,3.
七氟醚及笑气麻醉对老年大鼠空间认知能力的影响
Effects of Sevoflurane and Nitrous Oxide Anesthesia on Spatial Recognition in Aged Rats
摘要
Abstract
Objective:To compare the effects of sevoflurane and nitrous oxide anesthesia on spatial recognition in young and aged rats .Methods :Young(3 months ,n=12) and aged(18 months ,n=12) rats were divided randomly into anesthesia group (sevoflurane at 1 minimum alveolar concentration ,70% nitrous oxide ,30% oxygen ,for 4 h ,n=6) and control group(30%oxygen ,for 4 h ,n=6) .After 48 h ,training on spatial learning and memory (probe trial) were done in the Morris water maze for 6 days .Spatial exploration test was conducted at 24 h after training .Result:Sevoflurane and nitrous oxide exposure induced a significant deficit in spatial recognition in aged rats ,but not young rats .Conclusions :A significant deficit in spatial recognition in aged rats can be induced by sevoflurane and nitrous oxide exposure ,which may due to that the aged brain is more susceptible to anesthetic‐mediated changes .关键词
老年大鼠/学习记忆/七氟醚/笑气/Morris水迷宫Key words
Aged rats/Learning and memory/Sevoflurane/Nitrous oxide/Morris water maze分类
医药卫生引用本文复制引用
周国霞,朋立超..七氟醚及笑气麻醉对老年大鼠空间认知能力的影响[J].中国临床医学,2015,(1):73-75,3.基金项目
上海市闵行区科学技术委员会基金资助项目 （）
