中国临床医学Issue(2)：224-227,4.
乳腺导管内癌伴微浸润的病理和免疫组织化学特征分析
Analysis of Pathological and Immunohistochemical Features of Breast Ductal Carcinoma in Situ with Microin-vasion
摘要
Abstract
Objective:To compare the clinicopathological and immunohistochemical features of ductal carcinoma in situ(DCIS) with those of DCIS with microinvasion(DCIS‐MI) .Methods:The clinical data of 176 cases of DCIS‐MI and 184 cases of DCIS were collected and the clinicopathological and immunohistochemical features were analyzed .Results:The differences between the proportion of tumor maximal diameter≥2 .5 cm ,high grade ,comedo subtype in DCIS‐MI and those in DCIS ,were statistically significant(P<0 .01) .The differences in proportions of nipple with paget’s disease and axillary lymph node metastasis between the two groups were not statistically significant(P> 0 .05) .The difference between the two groups in immunohistochemical markers estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2),Ki‐67 , caveolin‐1 expression was statistically significant(P<0 .05) .Conclusion:DCIS‐MI shows high incidence in high grade ,comedo subtype ,tumor maximal diameter ≥ 2 .5 cm , ER negative , PR negative , caveolon‐1 positive , HER2‐positive , Ki‐67 proliferation index≥14% .关键词
乳腺癌/导管内癌伴微浸润/导管内癌/免疫组织化学Key words
Ductal arcinoma in situ with microinvasion/Ductal carcinoma in situ/Immunohistochemistry分类
医药卫生引用本文复制引用
徐明,叶辉,叶曼娜,余燕民..乳腺导管内癌伴微浸润的病理和免疫组织化学特征分析[J].中国临床医学,2015,(2):224-227,4.基金项目
上海市黄浦区优秀学科带头人项目；黄浦区卫计委科研项目 （）
