中国临床医学Issue(3)：305-309,5.
梗死心肌侧枝血管形成与缺氧诱导因子-1α及血管内皮生长因子A表达水平的关系及临床意义
Relationship between Myocardial Collateral Vessel Formation and the Levels of Hypoxia-Inducible Factor 1-alpha and Vascular Endothelial Growth Factor A and Its Clinical Significance
戴宇翔 1颜彦 1樊冰 1张峰 1姚康 1马剑英 1黄东 1葛均波 1王审 2李晨光 1黄浙勇 1陆浩 1常书福 1钱菊英 1葛雷 1王齐兵1
作者信息
- 1. 复旦大学附属中山医院心内科，上海 200032
- 2. 浙江省温岭市第一人民医院心内科，浙江温岭 317500
- 折叠
摘要
Abstract
Objective:The goal of this study was to analyze the clinical significance of relationship between myocardial collateral and the levels of hypoxia‐inducible factor 1‐alpha (HIF‐1α) and vascular endothelial growth factor A (VEGF‐A) in patients with coronary chronic total occlusion lesion .Methods:89 patients with coronary chronic total occlusion lesion confirmed by clin‐ical data and coronary angiography were identified .The levels of HIF‐1αand VEGF‐A were measured by ELISA ,and the rela‐tive expression of VEGF‐A of peripheral blood mononuclear cell (PBMC) were measured by real‐time PCR .The results were statistically analyzed by the statistical programme for social sciences (SPSS version 18 .0) and software SAS JMP 9 .0 .Results:Compared to Rentrop 0‐1 grade group (18/38 ,47 .4% ) ,Rentrop 2 (11/31 ,35 .5% ) and Rentrop 3 (3/20 ,15 .0% ) grade group had fewer diabetes mellitus .Rentrop 2 [(6 .67 ± 1 .41) mmol/L] and Rentrop 3 [(5 .48 ± 1 .26) mmol/L] grade group had low‐er fasting blood glucose than Rentrop 0‐1 grade group [(7 .24 ± 1 .39) mmol/L] .Rentrop 2 (12/31 ,38 .7% ) and Rentrop 3 (3/20 ,15 .0% ) grade group had fewer clinical heart failure (NYHA Ⅱ ~ Ⅳ grade) than Rentrop 0‐1 grade group (20/38 , 52 .6% ) .Rentrop 2 [(85 .5 ± 27 .7) pg/mL ,(139 .5 ± 42 .1) pg/mL] and Rentrop 3 [(103 .3 ± 30 .2) pg/mL ,(162 .6 ± 43 .3) pg/mL] grade group had higher levels of HIF‐1αand VEGF‐A than Rentrop 0‐1 grade group [(42 .0 ± 16 .1) pg/mL ,(76 .5 ± 32 .2) pg/mL] .Rentrop 2 (1 .31 ± 0 .46) and Rentrop 3 (1 .38 ± 0 .44) grade group had higher level of relative expression of VEGF‐A in PBMC than Rentrop 0‐1 grade group (1 .00 ± 0 .28) .Conclusions:Chronic and consistent ischemia and hypoxia in‐duced the increase of expression of HIF‐1αand VEGF‐A is important for establishment of coronary collateral ,increasing blood supply and improving the heart function and prognosis .关键词
冠状动脉慢性完全闭塞/冠状动脉侧枝循环/缺氧诱导因子-1α/血管内皮生长因子AKey words
Coronary chronic total occlusion/Coronary collateral circulation/Hypoxia-inducible factor 1-alpha/Vascu-lar endothelial grow th factor A分类
医药卫生引用本文复制引用
戴宇翔,颜彦,樊冰,张峰,姚康,马剑英,黄东,葛均波,王审,李晨光,黄浙勇,陆浩,常书福,钱菊英,葛雷,王齐兵..梗死心肌侧枝血管形成与缺氧诱导因子-1α及血管内皮生长因子A表达水平的关系及临床意义[J].中国临床医学,2015,(3):305-309,5.
