中国临床医学Issue(3)：322-326,5.
吸氧在急性心肌梗死患者行经皮冠状动脉介入治疗中的作用
Effects of Oxygen Therapy on Patients with Acute Myocardial Infarction during Emergency Percutaneous Coronary intervention
摘要
Abstract
Objective:To investigate the effects of oxygen therapy on patients with acute myocardial infarction (AMI) and without hypoxia ,who were treated with emergency percutaneous coronary intervention (PCI) .Methods:This study was a sin‐gle‐center ,prospective and randomized controlled study .A total of 143 patients with AMI and without hypoxia ,who were un‐dergoing emergency PCI were divided into oxygen group and control group .The patients in oxygen group inhaled oxygen at a flow rate of 5 L/min via nasal catheter for 24 hours ,the patients in control group inhaled air .Before and after PCI ,the patients in each group received standardized drug treatment (including anti‐thrombotic and anti‐ischemic drugs ,statins and angiotensin‐converting enzyme inhibitors) in Coronary Care Unit (CCU) .The situation of AMI and PCI were observed in the two groups . The clinical data including hospitalization time ,Global Registry of Acute Coronary Events (GRACE) score ,levels of cardiac troponin I(CTnI) ,myocardial‐specific isoenzyme of creatine kinase (CK‐MB) and N‐terminal pro‐B‐type natriuretic peptide (NT‐ProBNP) ,as well as the occurrence rates of cardiac arrhythmias ,cardiogenic shock and death were recorded and ana‐lyzed .Results:There were significant differences (all P<0 .05) between oxygen group and control group in peak concentra‐tions of serum CTnI[33 .40 (22 .10 ,75 .43) ng/mL vs .23 .70 (14 .83 ,45 .45) ng/mL] ,CK‐MB [(252 .70 ± 132 .20)U /L vs .(189 .66 ± 97 .05) U /L] and NT‐ProBNP [810(535 ,1390) pg/mL vs .406(240 ,846)pg/mL] as well as arrhythmia oc‐currence (13 vs .9 cases) .Bute there was no difference in cardiogenic shock ,death and hospitalization time between the two groups(all P>0 .05) .Conclusions:Oxygen therapy may have no benefit and even cause potential myocardial injury for AMI pa‐tients without hypoxia in the process of emergency PCI treatment .关键词
氧吸入疗法/急性心肌梗死/联合药物疗法/经皮冠状动脉介入治疗Key words
Oxygen therapy/Acute myocardial infarction/Combination drug therapy/Percutaneous coronary interven-t io n分类
医药卫生引用本文复制引用
陈军,王万虹,张荣林,丁浩,程勇..吸氧在急性心肌梗死患者行经皮冠状动脉介入治疗中的作用[J].中国临床医学,2015,(3):322-326,5.基金项目
江苏省宿迁市科技计划项目 （）
