中国老年保健医学Issue(2)：50-52,3.DOI:10.3969/j.issn.1672-4860.2014.02.023
32例替吉奥联合多西他赛治疗复发转移乳腺癌临床观察
The efficacy and toxicity of docetaxel combined wifh compound tegafur capsule on anthracycline-refractory recurrent meta-static breast cancel
庄民 1李艳 1卞宝祥 1宋子琰 1郑义同1
作者信息
- 1. 江苏省连云港市第一人民医院 肿瘤内科 222002
- 折叠
摘要
Abstract
Objective To investigate the efficacy and toxicity of docetaxel combined wifh compound tegafur capsule ( S-1) on an-thracycline-refractory recurrent metastatic breast cancell(ARMBC).Methods Thirty-two ARMBC patients were given intravenous 75mg/m2 docetaxel at day 1,and oral 40mg/m2 S-1 twice every day at day 1 to 1 4.Twenty-one days was one cycle and each patient received at least two cycles.Results Efficacy and toxcities could be evaluated in 32 patients,and there were 3 cases of complete re-mission(CR),14 cases of partial remission(PR),8 cases of stability(SD) and 7 cases of disease-progression(PD).The objective response rate ( CR+PR) was 53.1%and disease control rate ( CR+PR+SD) was 78.1%.The main toxicity was myelosuppression and gastrointestinal reactions ,which were mainly Ⅰ-Ⅱ degree,and could be welltolerated.Conclusion Good clinical efficacy were achieved in the therapy ofmetastatic breast cancer with docetaxel and S -1 combination regimen and toxic reactions are tolerable.关键词
替吉奥/多西他赛/复发转移性乳腺癌/化疗Key words
S-1/docetaxel/advanced breast cancer/chemotherapy引用本文复制引用
庄民,李艳,卞宝祥,宋子琰,郑义同..32例替吉奥联合多西他赛治疗复发转移乳腺癌临床观察[J].中国老年保健医学,2014,(2):50-52,3.
