中国老年保健医学Issue(3)：53-54,55,3.DOI:10.3969/j.issn.1672-4860.2014.03.021
氯沙坦对原发性高血压合并高尿酸血症患者血压及血尿酸水平的影响
Effect of losartan on blood pressure and uric acid in patients with primary hypertension concomitant with hyperuricemia
摘要
Abstract
Objective To evaluate the clinical efficacy of losartan on blood pressure and uric acid in patients with primary hy -pertension concomitant with hyperuricemia.Methods A total of 66 patients with primary hypertension concomitant with hyperurice-mia were randomly selected and divided into treatment group and control group ,33 cases for each.The former was treated with 50~100 mg/d losartan for 4 weeks while the latter with 10~20mg/d benazepril for 4 weeks.Blood pressure and uric acid before treat-ment and 1,4,8 weeks after treatment in both groups were measured by uric acid enzyme neutralization ,and clinical efficacies after 1-course treatment were evaluated.Results Blood pressure had no significant difference between two groups before treatment ,which decreased after treatment,and systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased evidently in both groups 8 weeks after treatment than treatment before (P<0.05 or P<0.01).After treatment,uric acid had different levels of decrease in both groups,which decreased more obviously in treatment group than in control group (P<0.01).Conclusion Losartan can re-duce the level of uric acid in patients with primary hypertension concomitant with hyperuricemia .关键词
氯沙坦/原发性高血压/高尿酸血症/血压/血尿酸Key words
losartan/primary hypertension/hyperuricemia/blood pressure/uric acid引用本文复制引用
姚喜芳..氯沙坦对原发性高血压合并高尿酸血症患者血压及血尿酸水平的影响[J].中国老年保健医学,2014,(3):53-54,55,3.基金项目
中国高校医学期刊临床专项资金项目(11321269) （11321269）
