摘要
Abstract
Objectives To assess the diagnostic value of glycated hemoglobin ( HbA1c) ,serum glycated albumin ( Glycated Al-bumin,GA) and fasting plasma glucose ( Fasting Plasma Glucose,FPG) to early diabetes ( Diabetes Mellitus ,DM) patients.Methods Patients who came to Taizhou Hospital of Zhejiang Provinceduring 2010~2013 and detected HbA1c,GA and FPG simultaneously were collected.The crowd were divided into diabetic group and non-diabetic group for the receiver operating characteristic curve ( Re-ceiver Operator Characteristic curve,ROC curves ) analysis.The cut-off value ,area under the curve( AUC) ,sensitivity and specifici-ty were calculated,the combined diagnostic sensitivity and specificity of HbA1c,GA and FPG were further analyzed.Results ①HbA1c,GA and FPG were higher in DM group than the non-DM group (HbA1c:9.14%vs.5.84%,P=0.000;GA:24.8mmol/L vs.13.8mmol/L,P=0.000;FPG:9.65mmol/L vs .5.77mmol/L,P=0.000).②The cut-off value ,AUC,sensitivity and speci-ficity of HbA1c in diagnosis of DM were 6.85%,0.911,84.2%,96.2%,respectively;The cut-off value ,AUC,sensitivity and spe-cificity of GA in diagnosis of DM were 17.5mmol/L,0.881,71.6%,93.6%,respectively;The cut-off value ,AUC,sensitivity and specificity of FPG in diagnosis of DM were 7.52mmol/L,0.836,70.2%,82.1%,respectively.③The combined sensitivity and spe-cificity of HbA1c,GA and FPG in diagnosing DM was 91.1%and 76.3%.Conclusions HbA1c,GA and FPG had diagnostic val-ue for DM individually,among the three,HbA1c had the maximum diagnostic performance.HbA1c,GA and FPG could be combined to improve the sensitivity in DM diagnosis,with important value in screening DM.关键词
糖化血红蛋白/血清糖化白蛋白/空腹血糖/糖尿病/ROC曲线/联合诊断Key words
Glycosylated hemoglobin/Glycated serum albumin/Fasting plasma glucose/Diabetes mellitus/ROC curve/Combined diagnosis
