中国老年保健医学Issue(2)：5-8,4.DOI:10.3969/j.issn.1672-4860.2015.02.001
分子分型基础上治疗老年舒张性心力衰竭的临床观察
The clinical observation of metoprolol efficacy and safty based on genotyping for elderly diastolic heart failure treatment
摘要
Abstract
Objectives To explore metoprolol clinical efficacy and safty based on genotyping for elderly diastolic heart failure ( DHF) treatment.Methods We selected 120 elderly patients with DHFand adopted case and control design.The fluorescence in situ hybridization was used in this study for genotyping ofβ1 receptor gene (ADRB1) and drug metabolizing enzymes gene(CYP2D6*10)., we adjusted the metoprolol sustained-release tablets dosage depending on the type of drug metabolism type, (CYP2D6*10 genotype) and the drug-sensitive type ( ADRB1 genotype) , Then follow the subjectives for 24 weeks.And compare the differ-ences of the clinic phentypes and efficacy as well as safty between two groups.Results ①Through the personal use of different do-ses of metoprolol extended release tablets based on genotyping, for the case groups, we have observed the significant drug treatment efficiency (91.5%vs.40.0%,P<0.05) when compare with control group.②There were significant difference in the left ventricu-lar diastolic function index between two groups (P<0.05), and the extent of each index change also had significant difference ( P<0.05) .③After gene-directed therapy,the incidence of adverse events and all-cause mortality and readmission rate of the observation group were significantly lower than the control group (P<0.05).Conclusions In the application of metoprolol therapy based on genotyping for elderly diastolic heart failure, we have achieved grate drug treatment efficiency and safty among elderly pa-tients who with DHF.The result has great guiding significance for clinical treatment strategy.关键词
美托洛尔/个体化用药/基因分子分型/老年舒张性心衰/临床疗效Key words
metoprolol/personal treatment/genotyping/elderly diastolicheart failure/clinical efficacy引用本文复制引用
隋小芳,王淑秋,黄佳滨,杨泽..分子分型基础上治疗老年舒张性心力衰竭的临床观察[J].中国老年保健医学,2015,(2):5-8,4.基金项目
黑龙江省教育厅科学技术研究项目（项目编号12541828），国家自然科学基金（81061120527，81370445，81472408），卫生部公益性研究基金（201302008）和国家科技部十二五支撑计划项目（2012BAI10B01）。Supported by The Science and Technology Research Project of Hei－longjiang Province Education Department （ No．12541828）； the National Natural Science Foundation of China （ No．81061120527，81370445，81472408）；Chinese Ministry of Health of the Public Welfare Research Fund （No．201302008）；Chinese Ministry of Sci－ence and Technology for the 12th Five Years National Program Fund．（No．2012BAI10B01）． （）
