中国老年保健医学Issue(2)：75-76,77,3.DOI:10.3969/j.issn.1672-4860.2015.02.028
美金刚联合多奈哌齐治疗中重度阿尔茨海默病的临床研究
The clinical research of the combination use of Memantine and Donepezil in the treatment of Moderate to Severe Alzheimer’s disease
摘要
Abstract
Objectives To evaluate the clinical efficacy of Memantine combined with Donepezil in the treatment of moderat to severe Moderate Alzheimer’s Disease.Methods A total of 76 patients with moderate to severe AD were randomly divided into two groups:The trial group was treated as Memantine combined with Donepezil, while the control group Donepezil only.All patients were received treatment for 52 weeks.Once every 4 weeks follow-up, The two groups were evaluated using different scales suan as Mini-Mental Status Examination subscale( MMSE) , Alzheimers′Disease Assessment Scale-cognitive subscale ( ADAS-Cog) , Activity of daily life subscale(ADL) and the Neuropsychiatric Inventory(NPI).Results 16 weeks later,there were significant differences in MMSE, ADAS-Cog, ADL and NPI scores of two groups(P<0.05);especially the scores of NPI decrease evidently (P<0.01) in the trial group at the 4th week.Patients in the trial group, as compared with those in the control group, There were not significant differences in the scores of MMSE, ADAS-Cog(P>0.05), but There were significant differences in the scores of ADL afetr 28th week(P<0.05), and there were significant differences in NPI scores afetr 4th week(P<0.05).Conclusions Donepezil can im-prove effectively the cognitive function, the daily living skills and psychological symptoms.Its combination with memantine is superi-or to its single use in improving the daily living skills and psychological symptoms.关键词
阿尔茨海默病/美金刚/多奈哌齐/认知功能Key words
Alzheimer’s Disease/Memantine/Donepezil/Cognitive function引用本文复制引用
彭乐,陈发秀..美金刚联合多奈哌齐治疗中重度阿尔茨海默病的临床研究[J].中国老年保健医学,2015,(2):75-76,77,3.
