中国老年保健医学Issue(3)：6-8,13,4.DOI:10.3969/j.issn.1672-4860.2015.03.002
地西他滨联合小剂量阿糖胞苷治疗老年急性髓系白血病临床观察
Clinical observation of decitabine combined with low dose cytarabine in older patients with acute myeloid leukemia
马树沛 1林梅2
作者信息
- 1. 青岛市市立医院 血液科 266011
- 2. 青岛大学医学院 病理教研室 266071
- 折叠
摘要
Abstract
Objectives To explore the clinical efficacy and safety of decitabine combined with low dose cytarabine in older pa-tients with acute myeloid leukemia.Methods 30 older patients with acute myeloid leukemia treated in hematological department enrolled from December 2012 to March 2014 were collected.10 of 30 cases were treated with decitabine combined with low dose cyt-arabine [decitabine 20mg/(m2· d) intravenous drip d1~5,cytarabine 25mg subcutaneous injections q12h d4~17];The other 20 ca-ses were only treated with low dose cytarabine(25mg subcutaneous injections q12 d1~21 ).The clinical outcome and adverse events in these patients were analyzed.Results 7 of 10 cases treated with decitabine combined with low cytarabinecompleted 5 courses, 1 of 10 cases completed 4 courses, 2 of 10 cases completed 3 courses;Among these 10 patients, 5 achieved complete remission( CR) , 3achieved partial remission, 2 were ineffective (died of severe infection);Among the other 20 cases treated only with low dose cyt-arabine, only 1 case achieved complete remission;5 achieved partial remission;14 were ineffective.Conclusions The proposal of decitabine combined with low dose cytarabine is more effective than that of only low dose cytarabine, and well tolerated for those ol-der patients with acute myeloid leukemia.关键词
地西他滨/老年/急性髓系白血病/阿糖胞苷Key words
decitabineAcute/myeloid/leukemia in elderly/patients引用本文复制引用
马树沛,林梅..地西他滨联合小剂量阿糖胞苷治疗老年急性髓系白血病临床观察[J].中国老年保健医学,2015,(3):6-8,13,4.
