中国老年保健医学Issue(3)：23-24,25,3.DOI:10.3969/j.issn.1672-4860.2015.03.008
血清PG与抗HpAb联合检测在胃癌筛查中的应用价值
Application value of serum PG and anti HpAb detection in screening of gastric cancer
官娜 1李金花 1刘冬 1马荣2
作者信息
- 1. 大连港医院 检验科 116015
- 2. 大连医科大学附属二院 检验科 116027
- 折叠
摘要
Abstract
Objectives To investigate clinical survey feasibility of the gastric cancer patients serum pepsinogen ( PG) and Heli-cobacter pylori antibody ( HpAb) as a marker for the detection of gastric cancer.Methods Enrolled patients were divided into three groups:normal control group of 50 cases, gastric cancer 114 cases, chronic atrophic gastritis ( CAG) group of 203 cases, ac-cording to the fibre gastroscopy and pathological cytology diagnosis.Using double antibody sandwich enzyme linked immunosorbent assay for detection of pepsinogenⅠ( PGⅠ) and pepsinogenⅡ( PGⅡ) level, calculate the PGR ( PGⅠ /PGⅡ) , using urease antibody colloidal gold method to qualitatively detect antibodies against Helicobacter pylori.Results The gastric cancer group’ s PG I and PGR levels were significantly lower than the normal control group, with significant differences between the two groups( P<0.01);the content change of PGⅡis little, no significant differences between the two groups (P>0.05);CAG group’s PG Ⅰand PGR levels were significantly lower than the normal control group, with significant difference between the two group ( P <0.01);the PG II content changes were little, no significant differences between the two groups (P>0.05);PGR and PGⅠhad no statistical significance in gastric cancer group and CAG group( P>0.05).Anti HP antibody positive rate in gastric cancer group and the CAG group was significantly higher than that in the normal control group, the difference was statistically significant (P<0.01);but it had no significant differences in gastric cancer group and CAG group ( P>0.05).Conclusions If combined detection of the serum PG and anti Helicobacter pylori antibody ( HpAb) are both negative, 85%gastric cancer can be discharged.it is feasible, as an effective indicator for early gastric cancer screening for large population.关键词
胃蛋白酶原/幽门螺杆菌/胃癌/慢性萎缩性胃炎Key words
pepsinogen/Helicobacter pylori/Gastric cancer/Atrophic gastritis引用本文复制引用
官娜,李金花,刘冬,马荣..血清PG与抗HpAb联合检测在胃癌筛查中的应用价值[J].中国老年保健医学,2015,(3):23-24,25,3.
