中国美容医学Issue(13)：45-51,7.
急性皮肤屏障损伤修复过程中各项生理物理参数的变化规律及LED红光对其干预作用的评价
Changing of biophysical parameters on skin barrier restoration and the effect of LED 630 nm light on it:an in vivo acute skin barrier disruption
摘要
Abstract
Objective Establish a model of acute barrier disruption,investigate the processes and dy⁃namic changes of skin biophysical parameters.To evaluate the interventional effect of LED red-light, narrow-spectrum(630±3)nm, on the skin barrier function restoration. Methods Repeated tape strip⁃ping with corneofix was applied on experiment sites,the measurement of TEWL,CAP,EI,MI,sebum con⁃tent(seb)was performed on the baseline and 2minutes after the model established,and then every 24h hours,by using non-invasive detection technology. Results TEWL,CAP,pH,EI rise sharply,while MI, seb falldown sharply when the model established.During the restoration,TEWL show a sustained down⁃ward trend before meet the baseline.CAP and seb first falldown then rise,while MI and EI show a cross⁃current trend.pH first regain the baseline.Relevance:According to the relevance analysis of these pa⁃rameters,there are positive or negative correlation between them,when significance level is below 0.05 or 0.01(P<0.05 or P<0.01).LEDs 630nm light can accelerate some key indicator of skin biophysical parometers to restore normal. Conclusion Biophysical parameters change regularly during skin barri⁃er restoration.The relevance among these parameters indicate that there exist interactions among them.The incoherent LED light with narrow spectrum,(630±3)nm,can accelerate the process of the re⁃pairment,which manifested in the middle-advanced stage.关键词
皮肤屏障/皮肤生理物理参数/相关性/630nm红光Key words
skin barrier/skin biophysical parameters/relevance/630nm light分类
医药卫生引用本文复制引用
赵欣研,田燕,汪黎,刘玮..急性皮肤屏障损伤修复过程中各项生理物理参数的变化规律及LED红光对其干预作用的评价[J].中国美容医学,2015,(13):45-51,7.基金项目
2015中华医学会-欧莱雅中国人健康皮肤研究项目 （）
