中国免疫学杂志Issue(8)：1015-1018,4.DOI:10.3969/j.issn.1000-484X.2014.08.002
PIMT对类风湿关节炎成纤维样滑膜细胞凋亡的影响
Influence of PIMT on apoptosis of fibroblast-like synoviocytes in rheumatoid ar-thritis
摘要
Abstract
To prove the influence of protein isoaspartyl-methyltransferase ( PIMT ) on the cell apoptosis of fibroblast-like synoviocytes of RA.Methods: The expression vector of PIMT was constructed and transfected in to the RA-FLS, the impact of PIMT on the cell apoptosis of RA-FLS was observed by overexpressing the vector of PIMT.Results:The mRNA and protein level of PIMT in RA-FLS was increased after transfected the vector of PIMT into RA-FLS;compared with the normal cultured RA-FLS and the RA-FLS transfected with the empty vectors ,the cell apoptosis level was also increased.Conclusion:The decreased expression level of PIMT in RA-FLS is an important reason for reduce apoptosis of RA-FLS,and PIMT can affect the imbalance of proliferation/ap-optosis in the RA-FLS.关键词
类风湿关节炎/成纤维样滑膜细胞/蛋白异天冬氨酰甲基转移酶/细胞凋亡Key words
Rheumatoid arthritis/Fibroblast-like synoviocytes/Protein isoaspartyl-methyltransferase/Cell apoptosis分类
医药卫生引用本文复制引用
张慧,宗明,李牛,虞珊珊,孙立山,范列英..PIMT对类风湿关节炎成纤维样滑膜细胞凋亡的影响[J].中国免疫学杂志,2014,(8):1015-1018,4.基金项目
国家自然科学基金项目（81373203，81302563）、上海市科技人才计划项目（12XD1404300）、上海市生物医药重点专项基金（11DZ1973800）和上海市卫生局青年基金项目（2012y109）支持。 （）
