中国免疫学杂志Issue(8)：1105-1107,3.DOI:10.3969/j.issn.1000-484X.2014.08.022
麻风病患者外周血IL-10与调节性T细胞的相关性研究
Correlation between interleukin-10 and T regulatory cells in leprosy patients
摘要
Abstract
To detect the correlation between Interleukin-10 and CD4+CD25+Foxp3+regulation T cells ( Treg) and to explore the significance and mechanism of them in leprosy patients.Methods:We used the cytometric bead arra (CBA) to detect the serum Interleukin-10 in 30 leprosy patients and we used flow cytometry to test the Treg cells in 51 leprosy persons.Results:The con-centration of serum IL-10 in leprosy patients(130.00±54.27)pg/ml was higher than normal people(15.64±7.11)pg/ml,(P<0.05);The percentage of Treg cells in leprosy patients(17.626±8.1977)%was higher than normal people(9.998±1.7062)%,(P<0.05).The relevance between IL-10 and Treg is positive and linear ,( P<0.05 ).Conclusion: The imbalance between IL-10 and Treg cells may lead to immune abnormal in leprosy patients.关键词
麻风病/IL-10/Treg/相关性Key words
Leprosy/IL-10/Treg/Correlation分类
医药卫生引用本文复制引用
李彩霞,陆林,周晓鸿,邹子宏,徐元品,王笑彬,丁文立,张晓虹,李晓岚..麻风病患者外周血IL-10与调节性T细胞的相关性研究[J].中国免疫学杂志,2014,(8):1105-1107,3.基金项目
云南省教育厅科学研究基金重点项目（2013Z111）、云南省应用基础研究面上项目（2009CD174）和2013年昆明医科大学附属延安医院院内课题。 （）
