中国免疫学杂志Issue(10)：1405-1407,3.DOI:10.3969/j.issn.1000-484X.2014.10.023
IL-17在类风湿关节炎患者外周血表达的临床意义
Clinical significance of IL-17 in peripheral blood of patients with rheumatoid ar-thritis
车昌燕 1张国华 1刘俊平 2王明亮1
作者信息
- 1. 山西医科大学汾阳学院，汾阳 032200
- 2. 山西省汾阳医院，汾阳 032200
- 折叠
摘要
Abstract
Objective:To explore the role and significance of IL-17 on the pathogenesis of rheumatoid arthritis ( RA).Methods:The levels of IL-17 mRNA in peripheral blood mononuclear cell ( PBMC) of 66 RA patients (32 active,34 inactive) and 44 healthy controls were detected by reverse transcription-polymerase chain reaction ( RT-PCR ).The levels of serum IL-17 were detected by enzyme-linked immunosorbent assay ( ELISA).The levels of RF were detected by immunoturbidimetric assay.The correlations of serum IL-17 and RF were analyzed.Results: In RA patients the levels of IL-17 mRNA in PBMC were significantly higher than those in healthy controls ( P<0.05 ) , but there was no difference between the active and inactive RA ( P>0.05 ).The serum IL-17 levels in active RA patients were significantly higher than those in inactive RA patients and healthy controls ( P<0.05 ).The levels of serum IL-17 were positively correlated with RF in RA patients.Conclusion: IL-17 and RF play an important role in the pathogenesis and pathology process of RA ,and IL-17 may be associated with RA activity.关键词
IL-17/类风湿关节炎/临床意义Key words
Interleukin-17/Rheumatoid arthritis/Clinical significance分类
医药卫生引用本文复制引用
车昌燕,张国华,刘俊平,王明亮..IL-17在类风湿关节炎患者外周血表达的临床意义[J].中国免疫学杂志,2014,(10):1405-1407,3.
