中国免疫学杂志Issue(12)：1679-1682,4.DOI:10.3969/j.issn.1000-484X.2014.12.021
血液透析对终末期肾病合并HBV病毒感染患者免疫功能的影响
Effects of hemodialysis on immune function of patients with end-stage nephropathy associated HBV virus infection
雷湫宇 1赵景宏 1唐建英1
作者信息
- 1. 第三军医大学第二附属医院肾内科，重庆 400037
- 折叠
摘要
Abstract
Objective:To investigate the effects of hemodialysis f on immune function of patients with end-stage nephropathy associated HBV virus infection.Methods:50 cases of patients with end-stage nephropathy associated HBV virus infection from June 2011 to June 2013 were randomly selected as observation group.50 cases of patients with end-stage renal disease as the control group.Patients in control group and observation group were treated with continuous hemodialysis therapy .24 h urinary protein ,serum al-bumin,blood urea nitrogen and creatinine in control group and observation group before and after treatment were analyzed .The regulatory T lymphocyte ,the CD8+T lymphocytes,perforin and granzyme B in peripheral blood in control group and observation group before and after treatment were analyzed by flow cytometry.Results:After dialysis treatment ,clinical symptoms and laboratory indexes of the two groups were significantly improved ( P<0.05 ).Clinical symptoms and laboratory indexes in control group and observation group after treatment had no statistical difference ( P>0.05 ).There was no significant change of immune function in the control group before and after treatment ( P>0.05 ).But the ratio of Treg cells and CD 8+T lymphocyte in observation group after treatment were sig-nificantly increased than that of before treatment ( P<0.05 ).Before treatment ,the active molecule perforin and granzyme B expression rate of T cells in the peripheral blood of observation group were higher than the control group ( P<0.05 ).After treatment ,Treg cell and CD8+T lymphocyte ratio were significantly decreased as well as perforin and granzyme B expression rate ( P<0.05 ).Conclusion:Compared with control group ,hemodialysis can significantly improve the immune function of the patients with end -stage nephropathy as-sociated HBV virus infection.关键词
血液透析/终末期肾病/HBV/免疫功能Key words
Hemodialysis/End-stage renal disease/HBV/Immune function分类
医药卫生引用本文复制引用
雷湫宇,赵景宏,唐建英..血液透析对终末期肾病合并HBV病毒感染患者免疫功能的影响[J].中国免疫学杂志,2014,(12):1679-1682,4.
