中国免疫学杂志Issue(1)：109-113,121,6.DOI:10.3969/j.issn.1000-484X.2015.01.023
不同磷脂肽段诱导的实验性自身免疫性脑脊髓炎模型病理特征多样性的研究
Study on diversity of pathological features induced by different phospholipid peptides in experimental autoimmune encephalomyelitis in Lewis rats
摘要
Abstract
Objective:To explore whether different phospholipid peptides could induce different pathological features of EAE in Lewis rats.Methods:Lewis rats were immunized with myelin basic protein 82-99 (MBP82-99),MBP68-86,and myelin oligodendroglia glycoprotein 35-55 (MOG35-55),respectively,and evaluated everyday for neurological scores.The cerebrum,brain stem,cerebellum and spinal cord of every rat were removed and pathological features observed.Results: Rats immunized with the two MBP peptides exhibited neurological signs of EAE wherein the central nervous system had extensive inflammation infiltration.The number of infiltrates in spinal cords in the two MBP peptides groups was higher than that in the cerebrums,brain stems and cerebellums.In spinal cords, there was no statistical difference of infiltrates between MBP82-99 and MBP68-86 groups;however,the both groups had more infiltrates than MOG35-55 group.Inflammatory cells were observed only in spinal cords of animals immunized with MOG35-55.Conclusion:This study provides certain evidence for understanding the diversity of pathological manifestations of EAE in Lewis rats.关键词
髓鞘碱性蛋白/髓鞘少突胶质细胞糖蛋白/Lewis大鼠/实验性自身免疫性脑脊髓炎/病理学特征Key words
Myelin basic protein/Myelin oligodendroglia glycoprotein/Lewis rat/Experimental autoimmune encephalomyelitis/Pathological features分类
医药卫生引用本文复制引用
郑梅梅,王拥军,张星虎..不同磷脂肽段诱导的实验性自身免疫性脑脊髓炎模型病理特征多样性的研究[J].中国免疫学杂志,2015,(1):109-113,121,6.基金项目
本文受北京市高校教育委员会项目（ PXM2011＿014226＿07＿000069）资助。 （）
