中国免疫学杂志Issue(2)：185-188,4.DOI:10.3969/j.issn.1000-484X.2015.02.010
双氢青蒿素对肺癌细胞株H1299增殖与放疗增敏的影响
Effect of dihydroartemisinin on cell proliferation and radiotherapy sensitization of lung cancer cell H1299
摘要
Abstract
Objective:To investigate the inhibitory effect of dihydroartemisinin on non-small cell lung cancer H1299 cells.Methods:Through the CCK-8 method for determining the IC 10 of dihydroartemisinin ,choose low dose IC 10 as the experimental concentration,CCK-8 to observe artemisinin in low doses of H1299 cell proliferation, cycle and the influence of radiation sensitivity.Results:IC10 of dihydroartemisinin was 14.87 μmol/L,dihydroartemisinin could inhibit proliferation of H 1299 cells,slow down the cell cycle , and increased the radiation sensitivity.Conclusion: Dihydroartemisinin can inhibit cell proliferation , cell cycle arrest in S phase ,increase the radiation sensitivity.关键词
双氢青蒿素/非小细胞肺癌/增殖/细胞周期/放疗敏感性Key words
Dihydroartemisinin/Non-small cell lung cancer/Proliferation/Cell cycle/Radiation sensitivity分类
医药卫生引用本文复制引用
廖奎,王志令,彭志平,李海玉,李娟..双氢青蒿素对肺癌细胞株H1299增殖与放疗增敏的影响[J].中国免疫学杂志,2015,(2):185-188,4.基金项目
本文为重庆市渝中区科委项目资助（20130141）。 （）
