中国免疫学杂志Issue(2)：230-235,6.DOI:10.3969/j.issn.1000-484X.2015.02.019
IL-23 R基因多态性与吉林人群强直性脊柱炎易感性的关联研究
Correlation between IL-23R gene polymorphisms and susceptibility of ankylo-sing spondylitis
摘要
Abstract
Objective:To investigate the correlation between single nucleotide polymorphism ( SNP ) of rs7517847 and rs10489629 on IL-23R gene and susceptibility of ankylosing spondylitis in Jilin.Methods:IL-23R gene polymorphisms of 188 cases on ankylosing spondylitis were detected by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) , compared with those of 100 cases of healthy control group.Results:The frequency distribution differences ,between AS group and comparison group of separate genotype and the allele on two SNPs (rs7517847 and rs10489629) both showed statistical significance (P<0.05).Meanwhile, by the assumed genetic way , compared homozygous mutant GG of rs 7517847 with TG+TT, compared homozygous mutant AA of rs10489629 with GA+GG,such frequency distribution difference between the above two groups also showed statistical significance ( P<0.05).Conclusion:Polymorphisms about IL-23R gene of the rs7517847 and rs10489629 are both associated with susceptibility of AS in Jilin.The risk of AS will be increased if the person both with G/A allele and GG/AA genotype , which may be one of susceptive factors by AS.关键词
强直性脊柱炎/白细胞介素23受体/单核苷酸多态性/易感性/基因Key words
Ankylosing spondylitis/Interleukin-23 receptor ( IL-23R )/Single nucleotide polymorphism ( SNP )/Susceptibility/Gene分类
医药卫生引用本文复制引用
张吉林,刘冲,单雪梅,宋玉国..IL-23 R基因多态性与吉林人群强直性脊柱炎易感性的关联研究[J].中国免疫学杂志,2015,(2):230-235,6.基金项目
本文为吉林省卫生厅资助项目（No.2010z087）。 （）
