中国免疫学杂志Issue(4)：490-496,7.DOI:10.3969/j.issn.1000-484X.2015.04.012
DC－CIK联合化疗对多发性骨髓瘤患者细胞免疫功能的影响
Effect on cellular immune functions in peripheral blood of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for multiple myeloma
赵霞 1许庆 2丁慧芳 1徐敏 1邢健 1鲁光 1孙彩凤 1刘国强1
作者信息
- 1. 胜利油田中心医院血液内科，东营 257000
- 2. 胜利油田机关医院，东营 257000
- 折叠
摘要
Abstract
Objective:To valuate the treatment value and analyse the effect on the cellular immune functions by studying the differences of T-lymphocyte subsets and CD4+CD25+Treg cells in peripheral blood after adoptive immunotherapy ( dendritic cells and cytokine-induced killer cells,DC-CIK) combined with chemotherapy on MM.Methods:50 patients with MM were randomly divided into two groups.24 patients in chemotherapy group were treated by chemotherapy only,26 patients in joint group were treated by adoptive immunotherapy( DC-CIK) combined with chemotherapy,and the clinical outcomes and the levels of T-lymphocyte subsets and CD4+CD25+Treg cells in peripheral blood between two groups were compared.Moreover,the differences of cellular immune indicators (Th1/Th2,the ratio of AgNOR,and TGF-β)between two groups were also compared.Results: After treatment,quality of life,clinical index and survival in joint group were better than in chemotherapy group( P<0.05);the proportion of CD3+CD8+,the ratios of CD4+CD25+,CD4+CD25+/CD4+and the level of TGF-βof joint group wes clearly lower than chemotherapy group(P<0.05),and the ratios of CD3+CD4+/CD3+CD8+, Th1/Th2 and AgNOR of joint group wes clearly higher than chemotherapy group .Conclusion: DC-CIK combined with chemotherapy could be an effective and promising treatment to patients with MM,and it maybe strengthen the anti-tumor action of bodies by regulating the balance between Th1 and Th2 reaction.关键词
多发性骨髓瘤/免疫疗法/树突细胞/杀伤细胞/T淋巴细胞,调节性/T淋巴细胞亚群/免疫,细胞Key words
Multiple myeloma/Immunotherapy/Dendritic cells/Killer cell/T-lymphocyte, regulatory/T-lymphocyte subsets/Immunity,cellular分类
医药卫生引用本文复制引用
赵霞,许庆,丁慧芳,徐敏,邢健,鲁光,孙彩凤,刘国强..DC－CIK联合化疗对多发性骨髓瘤患者细胞免疫功能的影响[J].中国免疫学杂志,2015,(4):490-496,7.
