中国免疫学杂志Issue(4)：531-533,536,4.DOI:10.3969/j.issn.1000-484X.2015.04.020
CHOP方案治疗前后外周 T 细胞淋巴瘤患者外周血 CD45 RA＋T 和CD45 RO＋T的变化特点
Change of CD45RA+and CD45RO+T cell in peripheral blood in peripheral T-cell lymphoma patients before and after CHOP chemotherapy
摘要
Abstract
Objective:To explore the change of initial and memory T cells in peripheral blood and their clinical significance in peripheral T cell lymphoma patients( PTCL) before and after CHOP chemotherapy.Methods:The proportion of CD4+CD45RA+T cells and CD4+CD45RO+T cells,CD8+CD45RA+T cells and CD8+CD45RO+T cells in peripheral blood from 20 PTCL patients before and after chemotherapy was detected by flow cytometry, the relationship between curative effect and T cell subset was further analyzed.Results:Before treatment,the proportion of CD4+and CD4+CD45RO+T cells in PTCL patients was significantly lower than that from the control group,while the proportion of CD4+CD45RA+,CD8+,CD8+CD45RO+and CD8+CD45RA+T cells was significantly higher( P<0.05 );after treatment, proportion of CD4+, CD4+CD45RO+T was significantly increased, CD4+CD45RA+, CD8+, CD8+CD45RO+,CD8+CD45RA+T was slightly decreased( P<0.05).Before and after treatment,higher proportion of CD4+CD45RA+T cells was found in response group compared with no response group.Conclusion: CHOP chemotherapy might influence the thymic output function in PTCL patients,patients with higher thymic output function may have better response to chemotherapy.关键词
外周T细胞淋巴瘤/CHOP方案/初始T细胞/记忆T细胞Key words
Peripheral T cell lymphoma/CHOP/naive T cells/Memory T cells分类
医药卫生引用本文复制引用
吕学文,王博,李扬秋..CHOP方案治疗前后外周 T 细胞淋巴瘤患者外周血 CD45 RA＋T 和CD45 RO＋T的变化特点[J].中国免疫学杂志,2015,(4):531-533,536,4.基金项目
本文为广东省科技计划（国际合作）项目（2012B050600023）。 （）
