中国免疫学杂志Issue(6)：728-731,4.DOI:10.3969/j.issn.1000-484X.2015.06.002
蠕虫感染的免疫调节作用在诱导器官移植免疫耐受中应用价值的探讨
Value of established solid-organ transplant tolerance from experience of host im-munomodulation with helminth infection
摘要
Abstract
Organ transplantation is the effective method to replace the function of the patient failed organ. But it is very disappoint that recipients have to receive the long-term immunosuppression regimens for prevention of allograft rejection. To induce allograft immune tolerance without immunosuppressant is in great demand. Although several tolerance strategies for organ transplant have been proposed, even some has already been tested in the 1st clinical trial, these strategies haven ' t approached to ideal efficacy. Helminths are remarkably successful parasites to achieve immunological tolerance to host immune response. It is now well established that the parasites′ success is the result of active immunomodulation of their hosts ' immune response. We suggest that injecting B cells from donor spleen and helminth soluble antigens, recipient might become tolerance to donor organ, but not tolerated to other antigens. Research based on this approach has great translated value for future clinic practice.关键词
蠕虫感染/免疫调节/器官移植/免疫耐受Key words
Helminthic infection/Immune regulation/Organ transplantation/Immune tolerance分类
医药卫生引用本文复制引用
明英姿,邹义洲..蠕虫感染的免疫调节作用在诱导器官移植免疫耐受中应用价值的探讨[J].中国免疫学杂志,2015,(6):728-731,4.基金项目
本文受国家自然科学基金项目(81273265)、湖南省科技重点项目(2013FJ2005)和湖南省医学卫生科技项目(B2013-003)等资助。 （81273265）
