中国普通外科杂志Issue(10)：1355-1361,7.DOI:10.7659/j.issn.1005-6947.2014.10.010
HSP27和claudin-10在结直肠癌中的表达及其临床意义
Expressions of HSP27 and claudin-10 in colorectal carcinoma and their clinical significance
摘要
Abstract
Objective: To investigate the expressions of HSP27 and claudin-10 in colorectal carcinoma (CRC) and the clinical signiifcance. <br> Methods:The expressions of HSP27 and claudin-10 in 50 specimens of CRC tissue, 25 specimens of colorectal adenoma (CRA) tissue, and 50 specimens of normal colorectal mucosal tissue were determined by immunohistochemical staining. hTe relationship between HSP27 and claudin-10 expressions in CRC, and the relations of HSP27 and claudin-10 expressions with clinicopathological factors and prognosis of the CRC patients were analyzed. <br> Results: In CRC, CAR and normal colorectal mucosal tissue, the positive expression rate of HSP27 was 54%, 20% and 16% respectively, with statistical signiifcance (P<0.001), and the positive expression rate of claudin-10 was 72%, 56% and 54% respectively, with no statistical difference (P>0.05). There was a positive correlation between HSP27 and claudin-10 expressions in CRC tissue (r=0.318,P=0.024). Univariate analysis showed that positive HSP27 expression was associated with lymph node metastasis (P<0.05), and the positive claudin-10 expression was related to tumor diameter, invasion depth and lymph node metastasis (allP<0.05). Survival analysis showed that the mean survival time in CRC patients with positive HSP27 or claudin-10 expression was signiifcantly shorter than in those with its negative expression (bothP<0.05). Multivariate analysis showed that the HSP27 and claudin-10 expressions together with lymph node metastasis were the independent risk factors for the prognosis of the CRC patients. <br> Conclusion: HSP27 expression is up-regulated in CRC tissue, which may probably be synergistic with claudin-10 to exert important effect on lymph node metastasis in CRC.关键词
结直肠肿瘤/热休克蛋白质类,小分子/连接蛋白类Key words
Colorectal Neoplasms/Heat-Shock Proteins, Small/Connexins分类
医药卫生引用本文复制引用
蒋锐,裴海平,葛华,曾亮..HSP27和claudin-10在结直肠癌中的表达及其临床意义[J].中国普通外科杂志,2014,(10):1355-1361,7.基金项目
国家自然科学基金资助项目（30872463）；湖南省自然科学基金资助项目（07JJ5016）。 （）
