中国普通外科杂志Issue(6)：823-827,5.DOI:10.3978/j.issn.1005-6947.2015.06.011
抗凝联合抗血小板聚集治疗预防糖尿病下肢动脉硬化闭塞症支架植入后再狭窄的疗效分析
Combined anticoagulation and antiplatelet therapy for prophylaxis of restenosis after stent placement for leg atherosclerosis obliterans in diabetic patients
苏少飞 1田玉峰 1陈林宝 1闫波1
作者信息
- 1. 宁夏回族自治区银川市第一人民医院 血管外科，宁夏 银川 750021
- 折叠
摘要
Abstract
Objective: To investigate the clinical effcacy of combined anticoagulation and antiplatelet aggregation therapy in prevention of restenosis atfer stent placement for leg atherosclerosis obliterans in diabetic patients. <br> Methods: Sixty-one diabetic patients with lower limb atherosclerosis obliterans were designated to observational group (30 cases) and control group (31 cases). Patients in observational group received warfarin plus cilostazol regimen, and aspirin plus cilostazol regimen was used in those in control group. Follow-up was performed for one year, and the incidence of restenosis and other relevant variables were compared between the two groups. <br> Results: hTe preoperative data were comparable between the two groups. During follow-up, the postoperative incidence of restenosis, late lumen loss and plasma D-dimer level in observation group were signiifcantly lower than those in control group (allP<0.05), while preoperative platelet aggregation rate, and blood glucose/lipid-related parameters as well as incidence of bleeding events showed no signiifcant difference between the two groups (allP>0.05). <br> Conclusion: Combined anticoagulation and antiplatelet therapy for prophylaxis of restenosis after stent placement for leg atherosclerosis obliterans in diabetic patients is safe and effective, so it is recommended to be used in clinical practice.关键词
闭塞性动脉硬化/糖尿病/移植物闭塞,血管Key words
Arteriosclerosis Obliterans diabetes/Diabetes Mellitus/Gratf Occlusion, Vascular分类
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苏少飞,田玉峰,陈林宝,闫波..抗凝联合抗血小板聚集治疗预防糖尿病下肢动脉硬化闭塞症支架植入后再狭窄的疗效分析[J].中国普通外科杂志,2015,(6):823-827,5.
