摘要
Abstract
Objective To investigate the changes of levels of transforming growth factor - β1 ( TGF - β1 )and lectin - like oxidized low density lipoprotein receptor - 1( LOX -1)and their correlation in patients with essential hypertension (EH). Methods A total of 80 EH patients who visited Center Hospital of Quzhou outpatient center from January to June 2012 were enrolled as hypertension group,and 25 healthy subjects as control group. SBP,DBP,mean blood pressure(MBP)were measured and the hypertension group divided into subgroups A(grade 1 hypertension group),B(grade 2 hypertension group), C(grade 3 hypertension group). Enzyme - linked immunosorbent assay was used to determine the levels of TGF - β1 ,LOX -1 and their correlation with BP analyzed. Results The levels of TGF - β1 ,LOX -1 and SBP,DBP,MBP were higher in hypertension group than in control group(P ﹤0. 05). Hypertensive patients classified according to the level of blood pressure,subgroup A 24 cases,subgroup B 27 cases,subgroup C 29 cases. There was significant difference in levels of TGF - β1 ,LOX -1 and SBP,DBP,MBP in 3 subgroups( P ﹤0. 05),and higher in subgroup C than in subgroups A,B,higher in subgroup B than in subgroup A(P ﹤0. 05). Correlation analysis showed that levels of TGF - β1 ,LOX -1 were positively correlated with SBP,DBP,MBP(r =0. 674,0. 562,0. 614;0. 825,0. 654,0. 729),and TGF - β1 positively with LOX -1( r =0. 710, P ﹤0. 05). Conclusion The levels of TGF - β1 ,LOX -1 are positively correlated with BP in EH patients. TGF - β1 , LOX -1 are risk factors of hypertension. So control of levels of TGF - β1 ,LOX -1 may help reduce BP levels in EH patients.关键词
高血压/转化生长因子β1/凝集素样氧化低密度脂蛋白受体-1/相关性Key words
Hypertension/Transforming growth factor beta1/Lectin-like oxidized low density lipoprotein receptor-1/Correlation分类
医药卫生
