中国全科医学Issue(14)：1684-1687,4.DOI:10.3969/j.issn.1007-9572.2014.14.031
多囊肾病的进展与肾脏纤维化
Progression of Polycystic Kidney Disease and Renal Fibrosis
摘要
Abstract
Polycystic kidney disease( PKD),a common hereditary kidney disease,can be divided,according to mode of inheritance,into autosomal dominant and autosmal recessive,and autosomal dominant PKD is the commonest,which will be analyzed specifically in this paper. For PKD,renal cyst growth and renal functional incapacitation is associated with pro-gressive fibrosis. Renal fibrosis,an important mechanism of progression-to-end-stage kidney disease( KD),leads to inci-dence of end-stage KD,the mechanism of which remains unknown. In PKD,the mechanisms of renal fibrosis include increas-ing expressions of transforming growth factor-β,interstitial collagen protein,epithelial-mesenchymal transition and plasmino-gen activator inhibitor and so on. Given the important role of renal fibrosis in PKD,preventing or slowing renal fibrosis can retard PKD progression. Effective anti-fibrosis therapy depends on the understanding of renal fibrosis mechanism. This paper is aimed to discuss the relationship PKD progression to renal fibrosis.关键词
多囊肾,常染色体显性/纤维化/发病机制Key words
Polycystic kidney,autosomal dominant/Fibrosis/Pathogenesis分类
医药卫生引用本文复制引用
宋东旭,郁胜强..多囊肾病的进展与肾脏纤维化[J].中国全科医学,2014,(14):1684-1687,4.基金项目
国家自然科学基金资助项目 （）
