中国全科医学Issue(15)：1700-1703,4.DOI:10.3969/j.issn.1007-9572.2014.15.003
维持性血液透析患者低剂量阿托伐他汀钙治疗对重组人促红细胞生成素用量的影响
Influence of Low - dose Atorvastatin Therapy on Recombinant Human Erythropoietin Dosage among Patients Undergo-ing Maintenance Hemodialysis
摘要
Abstract
Objective To investigate the effects of low - dose atorvastatin on recombinant human erythropoietin (rHuEPO)dosage among patients undergoing maintenance hemodialysis(MHD). Methods A total of 36 patients undergoing MHD at centre of blood purification in the First Affiliated Hospital of Guangxi Medical University from November 2011 to Novem-ber 2012,were selected as study subjects,among whom 18 patients who received atorvastatin therapy(10 mg/ d for 3 months) were selected as observation group,and 18 other patients who did not receive atorvastatin therapy were selected as control group. The levels of blood cholesterol,hemoglobin(Hb)and high sensitivity C - reactive protein(hs - CRP),erythropoietin resistance index( ERI)and rHuEPO dosage before treatment and 3 months after treatment were compared between the two groups. The dependent variable was the difference value(ΔERI)between ERI before treatment and ERI after treatment,the in-fluence factors of ΔERI were analyzed by generalized linear stepwise regression. Results There was no significant difference in levels of blood cholesterol,Hb and hs - CRP,ERI and rHuEPO dosage between two groups before treatment(P > 0. 05). After treatment,the levels of TC,HDL - C,LDL - C and hs - CRP,ERI and rHuEPO dosage in observation group were significantly lower than those in control group(P < 0. 05),Hb level in observation group was significantly higher than that in control group (P < 0. 05). The generalized linear stepwise regression analysis results showed that atorvastatin,ΔHb and ΔTC were independ-ent influence factors of the ΔERI( β value was 3. 62, - 0. 26 and 0. 99,respectively,all P < 0. 05). Conclusion Low -dose atorvastatin therapy for MHD patients can increase hemoglobin level,decrease hs - CRP level and ERI,and reduce the rHuEPO dosage.关键词
肾透析/红细胞生成素,重组/超敏C反应蛋白/阿托伐他汀钙Key words
Renal dialysis/Erythropoietin,recombinant/High sensitivity C - reactive protein/Atorvastatin分类
医药卫生引用本文复制引用
蒋晓波,廖蕴华,史应龙,谢恺庆,周红卫..维持性血液透析患者低剂量阿托伐他汀钙治疗对重组人促红细胞生成素用量的影响[J].中国全科医学,2014,(15):1700-1703,4.基金项目
广西壮族自治区教育厅科研立项（201106LX116）；广西壮族自治区卫生厅自筹经费科研课题 （）
