摘要
Abstract
Objective To evaluate the effect of tirofiban on the heart function and B-type brain natriuretic peptide ( BNP)level in patients with ST-segmentelevation myocardial infarction( STEMI)who received primary percutaneous coronary intervention(PCI). Methods From February 2011 to January 2013 one hundred and four patients of Nanfang Hospital,South-ern Medical University,with STEMI were randomly divided into observation group and control group, with 52 cases in each group. The observation group group was received tirofiban plus PCI and the control group was treated with PCI. TIMI grade 3 , TMP grade 3 of myocardial perfusion,the resolution of the sum of ST-segment elevation( sumSTR)90 minutes after the opera-tion,the serum BNP levels and heart function as well as major adverse cardiovascular events( MACE)were observed and com-pared between the two groups. Results The percentage of TMP 3 and sumSTR>50% in the observation group were significantly higher than those of the control group(P<0. 05). There was no statistically significant difference of TIMI grade 3 between the two groups(P>0. 05). The level of LVEF of the observation group was significantly higher than that of the control group 1 week after operation(P<0. 05). There were significant differences of the levels of LVEF,LVEDD and LVESD 4 weeks after opera-tion between the two groups(P<0. 05). Comparison results of within-group indicated that there were significant differences between LVEF,LVEDD 1 week after the operation and those 4 weeks after the operation in the observation group(P<0. 05). The control group after 4 weeks LVEF,LVESD compared with after 1 week,the difference was statistically significant( P <0. 05). There was significant difference in plasma BNP level between two groups before the operation,1 week and 4 weeks after the operation(P<0. 05). The BNP levels of the observation group 1 and 4 weeks after operation were significantly lower than that of the control groups(P<0. 05). Observation group after 4 weeks of plasma BNP levels below the preoperative and postop-erative 1 week,1 week after preoperative plasma BNP levels below(P<0. 05);the control group after 1,4 weeks preoperative plasma BNP levels below before(P<0. 05). The incidence of MACE was significantly lower in observation group than that in control group within 3 months postoperatively〔7. 7%(4/52)vs. 23. 1%(12/52),P<0. 05〕. Conclusion Tirofiban can improve the heart function and level of BNP and educe adverse events after operation in patients with acute STEMI who received primary PCI.关键词
心肌梗死/盐酸替罗非班/心功能/利钠肽,脑/血管成形术,经腔,经皮冠状动脉Key words
Myocardial infarction/Tirofiban hydrochloride/Heart function/Natriuretic peptide,brain/Angioplas-ty,transluminal,percutaneous coronary分类
医药卫生
