中国全科医学Issue(17)：1943-1945,3.DOI:10.3969/j.issn.1007-9572.2014.17.005
空腹血糖诊断糖尿病截点的探讨与评价
Fasting Plasma Glucose Cut-off Point for Diagnosis Diabetes
马辰星 1许颖 1康向辉 2郝士丹 3李丹玲 1张景义1
作者信息
- 1. 063000 河北省唐山市，河北联合大学附属开滦总医院内分泌科
- 2. 河北联合大学附属开滦总医院
- 3. 唐山钢铁集团有限责任公司医院内分泌科
- 折叠
摘要
Abstract
Background The widely - used diabetic criteria(FPG≥7. 0 mmol/ L)is not a so sensitive indicator for early diabetes diagnosis. Objective To explore the sensitivity and specificity of different FPG levels for diabetes diagnosis,to find a reasonable cut - off point diagnosing diabetes. Methods A 75 g oral glucose tolerance test(OGTT)was performed in pa-tients or healthy subjects from 2007 to 2013 in Kailuan General Hospital Affiliated to Hebei United University. Blood glucose (BG)at hours 0. 5,1. 0,2. 0,3. 0 after OGTT. Subjects with 2 hPG ≥ 11. 1 mmol/ L were enrolled in diabetes group (3 915),those with 2 hPG ﹤ 11. 1 mmol/ L in non - diabetes group(1 844). The correlation of FPG with 2 h FPG was ana-lyzed,ROC curve of FPG diagnosing diabetes drawn. Results In diabetes group,34. 4% had FPG ﹤ 7. 0 mmol/ L. FPG was not correlated linearly with age,gender(r = - 0. 025, - 0. 020,P ﹥ 0. 05),positively with 2 hPG(r = 0. 853,P ﹤ 0. 05). Linear regression analysis showed that FPG was 6. 13 mmol/ L or higher when 2 hPG≥11. 1 mmol/ L. ROC curve showed that the best cut - off point was 6. 13 mmol/ L. The sensitivity of FPG ≥6. 13 mmol/ L was superior to that of FPG ≥7. 0 mmol/ L (81. 97% ,65. 62% ,respectively). Conclusion The sensitivity of FPG≥6. 13 mmol/ L is superior to that of FPG≥7. 0 mmol/ L,and can reduce rate of missed diagnosis,which is good as the cut - off point of FPG diagnosis early diabetes.关键词
空腹血糖/葡萄糖耐量试验/糖尿病/诊断/筛查Key words
Fasting plasma glucose/Glucose tolerance test/Diabetes mellitus/Diagnosis/Screening分类
医药卫生引用本文复制引用
马辰星,许颖,康向辉,郝士丹,李丹玲,张景义..空腹血糖诊断糖尿病截点的探讨与评价[J].中国全科医学,2014,(17):1943-1945,3.
